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ANTI-PHOSPHO-LCK (PTYR505)

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ANTI-PHOSPHO-LCK (PTYR505) Suppliers list
Company Name: Riedel-de Haen AG  
Tel: 800 558-9160
Email:
Products Intro: Purity:affinity isolated antibody Remarks:affinity isolated antibody, buffered aqueous solution
Company Name: SIGMA-RBI  
Tel: 800 736 3690 (Orders)
Email:
Products Intro:
ANTI-PHOSPHO-LCK (PTYR505) Basic information
Product Name:ANTI-PHOSPHO-LCK (PTYR505)
Synonyms:ANTI-PHOSPHO-LCK (PTYR505);Anti-phospho-Lck (pTyr505) antibody produced in rabbit;Anti-lymphocyte-specific protein tyrosine kinase antibody produced in rabbit;Anti-p56lck antibody produced in rabbit;Anti-pp58lck antibody produced in rabbit;Anti-YT16 antibody produced in rabbit
CAS:
MF:
MW:0
EINECS:
Product Categories:LAntibodies for Kinase/Phosphatase Biology;Lymphocyte Specific Kinase (Lck);Alphabetical Index;Antibodies;Non-Receptor Tyrosine Kinase Antibodies
Mol File:Mol File
ANTI-PHOSPHO-LCK (PTYR505) Structure
ANTI-PHOSPHO-LCK (PTYR505) Chemical Properties
storage temp. −70°C
form buffered aqueous solution
Safety Information
WGK Germany -
MSDS Information
ProviderLanguage
SigmaAldrich English
ANTI-PHOSPHO-LCK (PTYR505) Usage And Synthesis
UsesA working concentration of 0.1-1.0 μg/mL is recommended for detection of human Lck protein by immunoblotting.
General DescriptionThe signalling in T cells is mediated by receptor and non-receptor protein tyrosine kinases (PTK). Among the family of non-receptors PTK, Lck is a lymphoid-specific cytosolic PTK essential for T-cell development and function. Lck is essential for selection and maturation of developing T cells in the thymus. It plays a significant role in T-cell receptors mediated signalling by constitutive association with CD4 and CD8 receptors. In addition, Lck undergoes phosphorylation and activation by association with CD2 molecule. Lck also plays a role in T-cell proliferation in response to IL-2 receptor pathway. The activity of Lck is known to be regulated by phosphorylation of two conserved tyrosine residues, tyrosine 505 (equivalent to tyrosine 529 in c-Src) and tyrosine 394 (equivalent to tyrosine 418 in c-Src). Phosphorylation at Tyr505 stabillizes Lck and renders it biologically inactive.
Anti-phospho Lck (pTyr505) specifically recognizes human Lck (pTyr505). Mouse (100% homology) and chicken (91.7% homology) are expected to react.
ANTI-PHOSPHO-LCK (PTYR505) Preparation Products And Raw materials
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