ALPHA1-ANTICHYMOTRYPSIN, HUMAN

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Company Name: Sigma-Aldrich  
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Products Intro: Product Name:α-Antichymotrypsin
CAS:141176-92-3
Purity:>=92.5% (SDS-PAGE) Package:0.1mg Remarks:A9285
Company Name: Shanghai Maclean Biochemical Technology Co., LTD  
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Products Intro: Product Name:α1-Antichymotrypsin, from human plasma
CAS:141176-92-3
Purity:>=92.5% (SDS-PAGE), lyophilized powder Package:100μg
Company Name: Shanghai Guchen Biotechnology Co., LTD  
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Products Intro: Product Name:α1-Antichymotrypsin, from human plasma
CAS:141176-92-3
Purity:92.5% (SDS-PAGE), lyophilized powder Package:100μg
Company Name: Suzhou Haiben Pharmaceutical Co., Ltd  
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Products Intro: Product Name:141176-92-3
CAS:141176-92-3
Purity:98% HPLC Package:10g;100g;1kg;10kg
Company Name: United States Biological  
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Products Intro: Product Name:Alpha 1 Antichymotrypsin, Human
ALPHA1-ANTICHYMOTRYPSIN, HUMAN Basic information
Product Name:ALPHA1-ANTICHYMOTRYPSIN, HUMAN
Synonyms:A1-ANTICHYMOTRYPSIN FROM HUMAN PLASMA;Antichymotrypsin from human plasma;α1-antichymotrypsin from human plasma;Human Alpha-1 AntiChymotrypsin;ANTI-ANTICHYMOTRYPSIN, ALPHA-1-, HUMAN;ANTI-AACT, HUMAN;ANTICHYMOTRYPSIN, ALPHA-1, HUMAN;AACT, HUMAN
CAS:141176-92-3
MF:
MW:0
EINECS:
Product Categories:proteins
Mol File:Mol File
ALPHA1-ANTICHYMOTRYPSIN, HUMAN Structure
ALPHA1-ANTICHYMOTRYPSIN, HUMAN Chemical Properties
storage temp. -20°C
form lyophilized powder
Safety Information
Hazard Codes B
WGK Germany 3
HS Code 3504009000
MSDS Information
ProviderLanguage
SigmaAldrich English
ALPHA1-ANTICHYMOTRYPSIN, HUMAN Usage And Synthesis
Usesα1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays.
General DescriptionKallikrein-3 (KLK3) or prostate specific antigen (PSA) is a serine protease. The protein contains a 371-residue N-terminal heavy chain, which is composed of four Apple domains. The PSA gene is localized to human chromosome 4q35. PSA is synthesized in the liver as a proenzyme known as prekallikrein. It is a key component of the kinin-generating pathways (PK system). The protein is involved in important physiological roles, such as blood pressure modulation, complement activation, and control and maintenance of inflammatory responses. KLK3b alleles are found to be associated with end-stage renal disease (ESRD) suggesting that variants in KLK3 gene might be linked with ESRD susceptibility.
SERPINA3 is also known as α-1-antichymotrypsin (ACT or AACT). The gene consists of five exons and is mapped to human chromosome 14q32.13. The protein contains 423 amino acids and belongs to the family of serpin superfamily of protease inhibitors. SERPINA3 inhibits the activity of pancreatic chymotrypsin, leukocyte, cathepsin G, mast cell chymases, human glandular, kallikrein 2 and kallikrein 3. Elevated expression of the protein has been observed in various types of carcinomas including breast carcinoma, hepatocellular carcinoma, prostate carcinoma and adenocarcinoma of the lung.
Biochem/physiol Actionsα1-Antichymotrypsin (α1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC).
ALPHA1-ANTICHYMOTRYPSIN, HUMAN Preparation Products And Raw materials
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