4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID
中文名称 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID |
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中文同义词 | 4-氧代-1,4-二氢-[1,10]邻二氮杂菲-3-羧酸;化合物1,4-DPCA;1,4-DPCA化学试剂 |
英文名称 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID |
英文同义词 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID;1,4-DPCA;TVBAVFFTADCWKG-UHFFFAOYSA-N;4-DPCA;HIF-PH,HIF/HIF Prolyl-Hydroxylase,HIF-1α,HIFs,FIH,P4HA1,P4HA2,1,4DPCA,healing,Inhibitor,Hypoxia-inducible factors,1,4 DPCA,wound,inhibit,1,4-DPCA,P4HA3;1,10-Phenanthroline-3-carboxylic acid, 4,4a-dihydro-4-oxo- |
CAS号 | 331830-20-7 |
分子式 | C13H8N2O3 |
分子量 | 240.21 |
EINECS号 | |
相关类别 | |
Mol文件 | 331830-20-7.mol |
结构式 |
4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 性质
沸点 | 419.5±45.0 °C(Predicted) |
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密度 | 1.52±0.1 g/cm3(Predicted) |
储存条件 | RT |
溶解度 | 可溶于 DMSO(升温时高达 15 mg/ml)。 |
形态 | 棕褐色固体。 |
酸度系数(pKa) | 2.55±0.20(Predicted) |
颜色 | 米白色 |
稳定性 | 可在-20°下的DMSO中的溶液保存长达2个月。 |
IC50: 2.4 µM (Collagen hydroxylation); 60 μM (Factor inhibiting HIF (FIH))
1,4-DPCA (24 hours) treatment specifically increases the expression of multiple target genes, including the proangiogenic target genes Vegfa and Hmox1 and proglycolytic targets Ldh-a, Pgk1, Pdk1, and Glut1 in mouse B6 cells.
1,4-DPCA treatment significantly reduces the colony sizes of T4-2 (10 μM 1,4-DPCA) and ZR-75-1 cells (20 μM 1,4-DPCA). 1,4-DPCA-treated T4-2 cells form polarized spheroids in 3D culture. 1,4-DPCA treatment significantly reduces invasive branches in DA-MB-157 (20 μM 1,4-DPCA) and MDA-MB-231 (10 μM 1,4-DPCA) cells.1,4-DPCA inhibits the proliferation of T4-2, ZR-75-1, MDA-MB-157 and MDA-MB-231 cells.
1,4-DPCA treatment suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) (PLGA) discs implanted in the peritoneal cavity for 28 days in mice. 1,4-DPCA is found to be effective at inhibiting collagen deposition within and on the outer surface of the disc, and also limited connective tissue ingrowth, but not to the extent of glucocorticoid inhibition.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 5mg | 600元 |
2024/04/30 | HY-121172 | 4-OXO-1,4-DIHYDRO-[1,10]PHENANTHROLINE-3-CARBOXYLIC ACID 1,4-DPCA | 331830-20-7 | 10mM * 1mLin DMSO | 660元 |