(+/-)-VESAMICOL HYDROCHLORIDE
中文名称 | (+/-)-VESAMICOL HYDROCHLORIDE |
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中文同义词 | 化合物 T22486;盐酸扎氟普汀 |
英文名称 | (+/-)-VESAMICOL HYDROCHLORIDE |
英文同义词 | (±)-VesamicolHCl (AH-5183);Ah-5183((+/-)-2-(4-phenylpiperidino) cyclohexanol;(±)-2-(4-Phenylpiperidino)cyclohexanol hydrochloride, AH-5183 hydrochloride;(+/-)-VESAMICOL HYDROCHLORIDE (AH-5183) >98%;(+/-)-VESAMICOL HYDROCHLORIDE;(+/-)-VESAMICOL HCL;(+/-)-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL HYDROCHLORIDE;AH-5183 HYDROCHLORIDE |
CAS号 | 120447-62-3 |
分子式 | C17H26ClNO |
分子量 | 295.85 |
EINECS号 | |
相关类别 | |
Mol文件 | 120447-62-3.mol |
结构式 | ![]() |
(+/-)-VESAMICOL HYDROCHLORIDE 性质
储存条件 | Store at RT |
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溶解度 | 低于pH8的水性缓冲液:1 mM |
形态 | 固体 |
颜色 | 白色 |
Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)
The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine.
(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.
Animal Model: | Male Wistar rats (120-300 g) |
Dosage: | 3 mg/kg |
Administration: | Intraperitoneal injection; once |
Result: | The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum. |
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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