2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE
中文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
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中文同义词 | 2-氯-N-((3,4-二甲氧苯基)甲基)乙酰胺;2-氯-N-(3,4-二甲氧基苄基)乙酰胺;2-氯-N-[(3,4-二甲氧苯基)甲基]乙酰胺;乙酰胺,2-氯-N-((3,4-二甲氧苯基)甲基)-;UBA5抑制剂(DKM 2-93);2-氯-N-((3;4-二甲氧苯基)甲基)乙酰胺 |
英文名称 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE |
英文同义词 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE;CHEMBRDG-BB 9070724;2-Chloro-N-((3,4-dimethoxyphenyl)methyl)acetamide;Acetamide, 2-chloro-N-((3,4-dimethoxyphenyl)methyl)-;Brn 2857211;N-(Dimethoxy-3,4 benzyl)-chloroacetamide;N-(Dimethoxy-3,4 benzyl)-chloroacetamide [french];2-chloro-N-(3,4-dimethoxybenzyl)acetamide(SALTDATA: FREE) |
CAS号 | 65836-72-8 |
分子式 | C11H14ClNO3 |
分子量 | 243.69 |
EINECS号 | 604-604-1 |
相关类别 | 细胞生物学试剂 |
Mol文件 | 65836-72-8.mol |
结构式 |
2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE 性质
熔点 | 116-118 °C(Solv: carbon tetrachloride (56-23-5)) |
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沸点 | 425.7±45.0 °C(Predicted) |
密度 | 1.194±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:≥150mg/mL(615.54mM) |
形态 | 固体 |
酸度系数(pKa) | 13.42±0.46(Predicted) |
颜色 | 白色至浅黄色 |
IC50: 430 μM (UBA5), 90 μM (PaCa2 cells), 30 μM (Panc1 cells)
Ubiquitin-like modifier activating enzyme 5 (UBA5) is a novel pancreatic cancer therapeutic target. DKM 2-93 impairs pancreatic cancer cell survival through covalently modifying the catalytic cysteine of UBA5, thereby inhibiting its activity as a protein that activates the ubiquitin-like protein UFM1 to UFMylate proteins. DKM 2-93 inhibits PaCa2 and Panc1 cells survival with IC 50 s of 90 and 30 μM, respectively.
DKM 2-93 daily treatment significantly impairs tumor growth of PaCa2 cells in vivo in tumor xenograft studies in immune-deficient mice without causing any weight loss or overt toxicity.
安全信息
危险品标志 | Xi |
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危险等级 | IRRITANT |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 50mg | 660元 |
2024/08/19 | HY-101836 | 2-CHLORO-N-(3,4-DIMETHOXYBENZYL)ACETAMIDE DKM 2-93 | 65836-72-8 | 10mM * 1mLin DMSO | 726元 |