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2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-

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2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Basic information
Product Name:2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-
Synonyms:2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;CFT-743
CAS:2154350-81-7
MF:C46H49ClN10O3
MW:825.4
EINECS:
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Mol File:2154350-81-7.mol
2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Structure
2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Chemical Properties
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MSDS Information
2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Usage And Synthesis
DescriptionCFT-743 is a potent BET degrader. In vitro, CFT-743 is more potent than a BET inhibitor (AZD5153) and a CDK9 inhibitor (dinaciclib) in 100% and 97% of 38 leukemia lines tested. In mice bearing HL60 tumors, CFT-743 has similar efficacy as dinaciclib (81% regression versus 99% tumor growth inhibition (TGI)).
2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- Preparation Products And Raw materials
Tag:2,6-Piperidinedione, 3-[4-[[1-[6-[4-[6'-(4-chlorophenyl)-1'-methylspiro[cyclopropane-1,4'-[4H][1,2,4]triazolo[4,3-a][1,4]benzodiazepin]-8'-yl]-1H-pyrazol-1-yl]hexyl]-4-piperidinyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-(2154350-81-7) Related Product Information