1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- manufacturers
- Lats-IN-1
-
- $67.00 / 1mg
-
2024-11-19
- CAS:1424635-83-5
- Min. Order:
- Purity: 99.82%
- Supply Ability: 10g
|
| 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Basic information |
Product Name: | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- | Synonyms: | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-;TRULI;Lats-IN-1(TRULI );Lats-IN-1;N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;(Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;inhibit,LatsIN1,YAP,Yes-associated protein,Lats IN 1,Inhibitor;Lats-IN-1, 10 mM in DMSO | CAS: | 1424635-83-5 | MF: | C18H14N4OS | MW: | 334.39 | EINECS: | | Product Categories: | | Mol File: | 1424635-83-5.mol | ![1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Structure](CAS/20210111/GIF/1424635-83-5.gif) |
| 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Chemical Properties |
density | 1.36±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: 83.33 mg/mL (249.20 mM) | form | A solid | pka | 12.30±0.40(Predicted) | color | White to light yellow |
| 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Usage And Synthesis |
Biological Activity | TRULI is a call penetrant, potent and non-toxic activator of Yap signaling. TRULI is an ATP-competitive inhibitor of Lats kinases (the core enzymes in Hippo signaling) th at induces robust Yap nuclear translocation and prevents Yap phosphorylation. TRULI induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. |
| 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Preparation Products And Raw materials |
|