| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:FINDY >=98% (HPLC)
CAS:1507367-37-4
Purity:NULL Package:25mg;5mg Remarks:NULL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:FINDY
CAS:1507367-37-4
Package:100mg/RMB 17500;25mg/RMB 10600;50mg/RMB 13800
|
| Company Name: |
Adipogen Life Sciences
|
| Tel: |
41-6192660-40 |
| Email: |
info@adipogen.com |
| Products Intro: |
Product Name:FINDY
|
4-Thiazolidinone, 5-[[4-methoxy-3-[2-(trimethylsilyl)ethynyl]phenyl]methylene]-2-thioxo-, (5Z)- manufacturers
- FINDY
-
- $2500.00 / 100mg
-
2024-11-19
- CAS:1507367-37-4
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | 4-Thiazolidinone, 5-[[4-methoxy-3-[2-(trimethylsilyl)ethynyl]phenyl]methylene]-2-thioxo-, (5Z)- Basic information |
| | 4-Thiazolidinone, 5-[[4-methoxy-3-[2-(trimethylsilyl)ethynyl]phenyl]methylene]-2-thioxo-, (5Z)- Chemical Properties |
| density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 25mg/mL, clear | | pka | 7.70±0.50(Predicted) | | form | powder | | color | light yellow to dark yellow |
| | 4-Thiazolidinone, 5-[[4-methoxy-3-[2-(trimethylsilyl)ethynyl]phenyl]methylene]-2-thioxo-, (5Z)- Usage And Synthesis |
| Uses | FINDY is a folding intermediate-selective inhibitor of DYRK1A. FINDY can inhibit Ser97 autophosphorylation with an IC50 value of 35 μM. FINDY can be used for the research of neurological disorder[1]. FINDY is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | FINDY is a cell-permeable thioxothiazolidinone derivative th at specifically targets newly synthesized cellular DYRK1A, but not DYRK1B or DYRK2, for proteasomal degradation by suppressing DYKR1A intramolecular Ser97 autophosphorylation, a necessary event for folding/maturation of newly translated DYRK1A. Unlike INDY and other ATP-competitive DYRK inhibitors, FINDY is ineffective against the kinase activity of DYRK1A, DYRK1B, DYRK2, or DYRK3 (IC50 >10 μM) and inhibits only five kinases (GSK3β, MARK4, PIM1, PIM3, PLK3) by over 75% at 10 μM among a panel of 271 other kinases. FINDY (2.5 μM) is shown to selectively rescue the developmental defect of Xenopus embryos induced by the overexpression of DYRK1A, but not DYRK1B, while INDY prodrug (2.5 μM) treatment indiscriminately prevents defect caused by both DYRK1A and DYRK1B expression.', 'FINDY is a structural analog of RD0392, a canonical ATP-competitive inhibitor of mature dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). | | References | [1] Yuka Miyazaki, et al. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur J Med Chem. 2022 Jan 5;227:113948. DOI:10.1016/j.ejmech.2021.113948 |
| | 4-Thiazolidinone, 5-[[4-methoxy-3-[2-(trimethylsilyl)ethynyl]phenyl]methylene]-2-thioxo-, (5Z)- Preparation Products And Raw materials |
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