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| | PSB CB5 Basic information |
| Product Name: | PSB CB5 | | Synonyms: | PSB CB5;CID-85469571;GPR18 IN 32;GPR18IN32;GPR18-IN-32;5H-Imidazo[2,1-b][1,3]thiazin-3(2H)-one, 2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-, (2Z)-;CID-85469571|||GPR18-IN-32 | | CAS: | 1627710-30-8 | | MF: | C20H17ClN2O2S | | MW: | 384.88 | | EINECS: | | | Product Categories: | | | Mol File: | 1627710-30-8.mol |  |
| | PSB CB5 Chemical Properties |
| Boiling point | 549.9±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 25 mg/ml) | | form | solid | | pka | -1.84±0.20(Predicted) | | color | Pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | PSB CB5 Usage And Synthesis |
| Description | PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50?= 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1? Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2 | | storage | Store at -20°C | | References | 1) Rempel?et al. (2014),?Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5?632
2) Flegel?et al.?(2016),?Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep.,?6?32255 |
| | PSB CB5 Preparation Products And Raw materials |
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