| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:LCAHA;LCAHA
CAS:117094-40-3
Purity:98% Package:10 mg;100 mg;25 mg;50 mg
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| Company Name: |
RD International Technology Co., Limited
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| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:LCAHA
CAS:117094-40-3
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| | Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- Basic information |
| | Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- Chemical Properties |
| density | 1.088±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 9.45±0.20(Predicted) | | color | White to off-white |
| | Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- Usage And Synthesis |
| Biological Activity | LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].
LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1]. | | References | [1]. Katarzyna Magiera, et al. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol. 2017 Apr 20;24(4):458-470.e18. |
| | Cholan-24-amide, N,3-dihydroxy-, (3α,5β)- Preparation Products And Raw materials |
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