| Company Name: |
Guangzhou Ruitai Chemical Co., Ltd. Gold
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| Tel: |
18344585702 |
| Email: |
550795326@qq.com |
| Products Intro: |
Product Name:3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester
CAS:303141-21-1
Purity:98% Package:1g/RMB 1200;5g/RMB 4500
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| | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Basic information |
| Product Name: | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester | | Synonyms: | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester;DC-S239;Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate;Histone Methyltransferase,Ethyl 2 amino 4 methyl 5 [(3 nitrophenyl)carbamoyl]thiophene 3 carboxylate,anti-cancer,HL60,SET7 inhibitor,MV4-11,MCF7,Ethyl 2amino4methyl5[(3nitrophenyl)carbamoyl]thiophene3carboxylate,inhibit,Inhibitor | | CAS: | 303141-21-1 | | MF: | C15H15N3O5S | | MW: | 349.36 | | EINECS: | | | Product Categories: | | | Mol File: | 303141-21-1.mol | ![3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Structure](CAS/20210305/GIF/303141-21-1.gif) |
| | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Chemical Properties |
| Boiling point | 479.4±45.0 °C(Predicted) | | density | 1.440±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (357.80 mM; Need ultrasonic) | | pka | 11.12±0.70(Predicted) | | form | Solid | | color | Yellow to orange |
| | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Usage And Synthesis |
| Biological Activity | DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity[1].
DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, while it inhibits SET7 by 90% at concentrations of 100 μM[1].DC-S239 (0-100 μM, 120 h) can inhibit the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner but no significant effect on the activity of HCT116 and DHL4 cells[1]. | | References | [1]. Fanwang Meng, et al. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem. 2015 Oct 22;58(20):8166-81. |
| | 3-Thiophenecarboxylic acid, 2-amino-4-methyl-5-[[(3-nitrophenyl)amino]carbonyl]-, ethyl ester Preparation Products And Raw materials |
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