P11149

P11149 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:P11149
CAS:164724-79-2
Package:25mg;1310USD|100mg;2590USD|50mg;1710USD
Company Name: Kaifeng Mingren Pharmaceutical Co.,LTD  
Tel: 0371-65741762
Email: sales@hasunny.com
Products Intro: Product Name:P11149
CAS:164724-79-2
Purity:98% Package:10mg
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Products Intro: Product Name:P11149
CAS:164724-79-2
Purity:>=99% Package:10mg;50mg;100mg;5mg
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:P11149
CAS:164724-79-2
Package:25mg/RMB 12800;100mg/RMB 21500;50mg/RMB 16800

P11149 manufacturers

  • P11149
  • P11149 pictures
  • $1310.00 / 25mg
  • 2024-10-28
  • CAS:164724-79-2
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
P11149 Basic information
Product Name:P11149
Synonyms:P11149;P11149,P-11149
CAS:164724-79-2
MF:C27H34ClNO4
MW:472.02
EINECS:
Product Categories:
Mol File:164724-79-2.mol
P11149 Structure
P11149 Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (211.86 mM; Need ultrasonic)
form Solid
color White to off-white
Safety Information
MSDS Information
P11149 Usage And Synthesis
Biological ActivityP11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats[1].P11149 exhibits T1/2(el) of 2.4 h and Cmax of 585 ng/mL in rat plasma[1].
References[1]. G M Bores, et al. Pharmacological evaluation of novel Alzheimer’s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. J Pharmacol Exp Ther. 1996 May;277(2):728-38.
P11149 Preparation Products And Raw materials
Tag:P11149(164724-79-2) Related Product Information