| Company Name: |
Guangzhou Ruitai Chemical Co., Ltd. Gold
|
| Tel: |
18344585702 |
| Email: |
550795326@qq.com |
| Products Intro: |
Product Name:YTX-465
CAS:2225824-53-1
Purity:95% Package:100mg/RMB 1500;500mg/RMB 5000
|
|
| | YTX-465 Basic information |
| Product Name: | YTX-465 | | Synonyms: | YTX-465;YTX-465Chemical Structure;YTX-465,α-synuclein,YTX465,fatty desaturation,Stearoyl-CoA Desaturase (SCD),Inhibitor,YTX 465,Parkinson’s disease,inhibit,synucleinopathies;Benzamide, N-[2-[4-[3-(1,3-dimethyl-1H-indazol-6-yl)-1,2,4-oxadiazol-5-yl]-1-piperidinyl]-2-oxoethyl]- | | CAS: | 2225824-53-1 | | MF: | C25H26N6O3 | | MW: | 458.51 | | EINECS: | | | Product Categories: | | | Mol File: | 2225824-53-1.mol |  |
| | YTX-465 Chemical Properties |
| density | 1.38±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (218.10 mM; Need ultrasonic) | | pka | 13.77±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | YTX-465 Usage And Synthesis |
| Biological Activity | YTX-465 is a stearoyl-CoA desaturase (Ole1/SCD) inhibitor. YTX-465 inhibits Ole1 and SCD1 with IC50s of 0.039 μM and 30.4 μM, respectively. YTX-465 can be used in the research of Parkinson's disease and other synucleinopathies[1].
YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue[1].YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast[1].YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop[1].YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM[1].YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast[1]. | | References | [1]. Vincent BM, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018 Dec 4;25(10):2742-2754.e31. |
| | YTX-465 Preparation Products And Raw materials |
|