| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:Gly3-VC-PAB-MMAE
CAS:2684216-48-4
Purity:>=99% Package:10g Remarks:ADC
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| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
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| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:Gly3-VC-PAB-MMAE
CAS:2684216-48-4
Purity:>=99% Package:100mg;50mg;5mg;10mg
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | 4-[[(2S)-2-[[(2S)-2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate | | CAS: | 2684216-48-4 | | MF: | C64H103N13O15 | | MW: | 1294.58 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![INDEX NAME NOT YET ASSIGNED Structure]() |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| Boiling point | 1419.3±65.0 °C(Predicted) | | density | 1.205±0.06 g/cm3(Predicted) | | pka | 13.29±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Biological Activity | Gly3-VC-PAB-MMAE consists a cleavable ADC linker (Gly3-VC-PAB) and a potent tubulin inhibitor (MMAE). Gly3-VC-PAB-MMAE can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. | | References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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