| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:(R)-GSK-3685032
CAS:2170140-50-6
Purity:98% HPLC LCMS Package:100mg;500mg;1g
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| Company Name: |
Wuhan WinYuanBei Trading Company
|
| Tel: |
86-13349903920; 13349903920 |
| Email: |
869523959@qq.com |
| Products Intro: |
Product Name:Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)-
CAS:2170140-50-6
Purity:98+% Package:1kg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:(R)-GSK-3685032
CAS:2170140-50-6
Purity:详情请点击官网 Package:1 mg
|
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| | Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Basic information |
| | Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Chemical Properties |
| Boiling point | 669.4±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | solubility | DMSO : 60 mg/mL (142.68 mM; Need ultrasonic) | | form | Solid | | pka | 14.65±0.50(Predicted) | | color | White to off-white |
| | Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Usage And Synthesis |
| Biological Activity | (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2]. | | References | [1]. Adams, Nicholas David, et al. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727A1. [2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017. |
| | Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]-, (αR)- Preparation Products And Raw materials |
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