Welcome to chemicalbook!
Chinese English Japanese Germany Korea
+1 (818) 612-2111
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structure Search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog > (+)-EPIBATIDINE DIHYDROCHLORIDE
(+)-EPIBATIDINE DIHYDROCHLORIDE
  • (+)-EPIBATIDINE DIHYDROCHLORIDE
  • (+)-EPIBATIDINE DIHYDROCHLORIDE

(+)-EPIBATIDINE DIHYDROCHLORIDE NEW

Price $8 $2 $0.8
Package 1kg 25kg 100kg
Min. Order: 1kg
Supply Ability: g-kg-tons, free sample is available
Update Time: 2024-04-08

Product Details

Product Name: (+)-EPIBATIDINE DIHYDROCHLORIDE CAS No.: 148152-66-3
Min. Order: 1kg Purity: 99%
Supply Ability: g-kg-tons, free sample is available Release date: 2024/04/08
Lead time: In stock, ready for shipment In stock: bag/bottle/drum/IBC
COA, MSDS: Available, contact us for details Origin: Manufacturer, advantage product
Delivery : By express, by air, by sea NAME: Sun

1. Materials information

Names

Name(+)-epibatidine dihydrochloride

 (±)-Epibatidine Biological Activity

Description(±)-Epibatidine is a nicotinic agonist. (±)-Epibatidine is a neuronal nAChR agonist.
Related Catalog
Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease
Target

nAChR[1]

In VitroIntracerebroventricular injection of (±)-Epibatidine (0.1 μg) significantly increases intercontraction interval (ICI) but does not change pressure threshold (PT) or maximal voiding pressure (MVP), whereas 1 μg of (±)-Epibatidine increases PT and MVP (P<0.05) and decreased ICI. A low intravenous dose of (±)-Epibatidine (0.001-0.1 μg) has no effect; however, a large dose of (±)-Epibatidine (1 μg) significantly decreases ICI and increases MVP (P<0.05) but does not change PT (P>0.05). (±)-Epibatidine has not only a potent stimulatory effect on nAChR subtypes in the brain (α4β2) but also in sympathetic and parasympathetic ganglia (α3β4) and at the neuromuscular junction (α1β1γδ) [1].
Animal AdminRats[1] Voiding is studied in urethane-anesthetized (1.2 g/kg sc) or awake female Sprague-Dawley rats (250-300 g). In all experiments, control cystometrograms (CMGs) are recorded for ~2 h before intracerebroventricular and intravenous injection of vehicle or (±)-Epibatidine solutions. Dose-response curves are constructed by administering increasing doses of (±)-Epibatidine [0.001-1 μg in 1 μL intracerebroventricularly (icv); 0.001-1 μg in 200 μL iv] at 30-min to 2-h intervals. (±)-Epibatidine is administered ~30 min after vehicle (aCSF, 1 μL icv; or saline solution, 200 μL iv). Chlorisondamine (10 μg, 1 μL icv) is injected 10-30 min before (±)-Epibatidine via the intracerebroventricular route in some experiments to block the effect of the agonist. The intravesical pressure to induce micturition (PT), MVP, and intercontraction interval (ICI; the interval between voids or reflex bladder contractions) are measured and converted into percent change from control values[1].
References

[1]. Lee SJ, et al. Effect of (+/-)-epibatidine, a nicotinic agonist, on the central pathways controlling voidingfunction in the rat. Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R84-90.

 Chemical & Physical Properties

Molecular FormulaC11H13ClN2
Molecular Weight208.69
PSA24.92000
LogP4.27570
Top Suppliers:I want be here

  • Dayang Chem (Hangzhou) Co., Ltd.

  • China

  • Product Name: (+)-EPIBATIDINE DIHYDROCHLORIDE

  • Price:$Inquiry/100g$Inquiry/1kg$Inquiry/100kg$Inquiry/1000kg

  • Purity: 98.0%

  • Stocking Period: Inquiry

  • Contact: Ms Wang

Get all suppliers and price by the below link:

(±)-Epibatidine suppliers

(±)-Epibatidine price

Related Compounds:More...
(±)-Epibatidine,(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
140111-52-0
(±)7(8)-DiHDPA
168111-93-1
(±)-Amiflamine
77502-96-6
(±)13(14)-EpDPA
895127-64-7
(±)-Equol
94105-90-5
(±)-Carbinoxamine-d6
1216872-59-1
(±)-ErSO
2407860-40-4
(±)-1,2-O-isopropylidene-myo-inositol
6404-82-6
(±)10(11)-EpDPA
895127-65-8




2. Packaging of materials

  • For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.

  • For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product. 

                             Or smaller package 1kg/bottle, 10kgs/bottle as request. 


Article illustrationArticle illustration


3. Shipping & Delivery

  • By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

Article illustration


  • By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

Article illustration


  • By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

Article illustration


4. Contact information

For more details, pls contact us freely.

Email address: sun@fdachem.com

Mob: 86 13526505137

WhatsApp/Skype/Wechat/LINE: 8613526505137



















Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.

You may like

Recommended supplier

Product name Price   Suppliers Update time
Daclatasvir Dihydrochloride
 $0.00/1g
VIP1Y
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
2024-09-05
Ethylenediamine dihydrochloride
 $25.00/1kg
VIP1Y
hebei hongtan Biotechnology Co., Ltd
 2024-05-16
Histamine dihydrochloride
 $339.00/1kg
VIP4Y
Shanghai UCHEM Inc.
 2023-11-16

Henan Fengda Chemical Co., Ltd

1YR ChinaChina
webchat
  • Since: 2023-02-10
  • Address: Room 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro
INQUIRY