Mk-677

1. Ibutamoren (INN) (developmental code names MK-677, MK-0677, L-163,191) is a non-peptidic, potent, long-acting, orally-active, and selective agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the grow-th hormone (GH)-stimulating action of the endogenous hormone ghrelin.

2. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including GH and in-sulin-like grow-th factor 1 (I-GF-1), but without affecting cortisol levels.

3. It is currently under development as a potential treatment for reduced levels of these hormones, such as in children or elderly adults with grow-th hor-mone deficiency, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly.

4. It also alters metabolism of body fat and so may have application in the treatment of obesity.Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn’t require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis.

5. Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day. Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs.

 Mk-677 Benifit:

1. Enantiomeric separation of the novel growth hormone secretagogue MK-0677 by capillary zone electrophoresis.

2. Once daily dosing with MK-677, an orally active GH secretagogue, stimulates bone turnover in elderly subjects based on elevations in biochemical markers of bone resorption and formation.

3. MK-677 (ibutamoren mesylate) for the treatment of patients recovering from hip fracture: A multicenter, randomized, placebo-controlled phase IIb study

4. Nutrobal (Mk-677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits: