β-Nicotinamide Mononucleotide

β- Nicotinamide Mononucleotide Properties Melting Point 166 ° C (dec.) Storage Conditions -20 ° C Solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) Form Solid Color WhitetoYellowMerck136697BRN3570187 Stability VeryHygroscopicInchIKeyDAYLJWODMCOQEW-TURQNECASA-N β- Usage and synthesis method characteristics of nicotinamide single nucleotide β- The appearance of nicotinamide mononucleotide is white to slightly yellow, and it is a crystalline powder with no obvious odor. Introduction: Nicotinamide mononucleotide, also known as β- Nicotinamide mononucleotide (NMN) is a synthetic substrate for coenzyme I, and NMN is also used in anti-aging research. Research has shown that, β- NMN can also regulate insulin secretion and affect mRNA expression levels, β- NMN has broad application prospects in the field of medical treatment. β- Nicotinamide mononucleotides are products of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reactions and key NAD+intermediates. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances insulin sensitivity in the liver and partially restores gene expression related to oxidative stress, inflammatory response and circadian rhythm through SIRT1 activation. Nicotinamide mononucleotide (NMN for short) is an inherent substance in the human body, and is also rich in some fruits and vegetables, including broccoli, cabbage, etc. Used in mammals, β- Nicotinamide mononucleotides are generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), followed by NAD+production under the catalysis of nicotinamide mononucleotides adenosine transferase. Nicotinamide mononucleotides are a direct way to supplement NAD+. Nicotinamide mononucleotides significantly enhance the repair ability of intracellular DNA damage, ultimately achieving the effect of reversing aging. Nicotinamide mononucleotides are converted into essential "nicotinamide adenine dinucleotide (NAD)" substances for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that the human body could originally generate, and research has confirmed that the content of NAD in the body decreases with age. application β- Nicotinamide mononucleotide is the precursor of cofactor NAD+of longevity protein in human body. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugars, fats, and amino acids, and participating in energy synthesis; NAD+is the only substrate for CoI consuming enzymes (DNA repair enzyme PARP, longevity protein Sirtuins, and cyclic ADP ribose synthase CD38)/