Product Details
| Product Name:
0990CL |
CAS No.:
511514-03-7 |
| Purity:
98.86% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名称 | 0990CL |
| 描述 | 0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability. |
| 体外活性 | 0990CL (at a concentration of 30 μM with a 30-minute pre-treatment) exhibits preferential binding to Gαi1 compared to Gαq. It displays selectivity towards Gαi and Gαq, resulting in a maximum reduction of endpoint fluorescence by 38±8% and 10%, respectively. Treatment with 0990CL (100 nM to 1 μM , 24 h) restores α2AR/Gαi-mediated cAMP levels induced by Fsk and UK14304 in HEK293 GloSensor cells. At a dosage of 100 nM, it reinstates 31% of the reduced cAMP levels[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45.0 mg/mL (131.0 mM), Sonication is recommended.
|
| 关键字 | 0990CL |
| 相关产品 | UNC0006 | Bithionol | HJC0197 | Adenosine receptor A1 antagonist 5 | HJC0350 | TDI-10229 | I942 | MRE3008F20 | Torbafylline | 2-PCCA hydrochloride | ESI-05 | GAT211 |
| 相关库 | 经典已知活性库 | 膜蛋白靶向化合物库 | 抑制剂库 | 已知活性化合物库 | GPCR靶点分子库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$213.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-16 |
United States