11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | China | Manufacturer

Price	$30
Package	1kg

Product Details

Product Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride	CAS No.: 111974-74-4
Min. Order: 1kg	Purity: 98%
Supply Ability: 2000kg	Release date: 2024/06/26

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties

Melting point	180-184°C
storage temp.	Inert atmosphere,2-8°C
solubility	Soluble in DMSO, Methanol, Distilled Water
form	solid
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI	InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey	MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES	C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference	111974-74-4(CAS DataBase Reference)

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Usage And Synthesis

Description	Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical Properties	11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Uses	11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Uses	N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References	1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709

Packing &shipping&Payment

Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :

Quantity(Kilograms)	1 - 10000	>10000
Est. Time(days)	5	To be negotiated

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Company Profile Introduction

Hebei Hongtan Technology Co., Ltd. was established in 2018. In 2019, the Ministry of Foreign Trade was established. The team has 10 members and has invested $300,000 in product development. Our goal is to make everyone can use inexpensive beauty products, the company's products have passed the CE certification, the main products are slimming peptide, anti-wrinkle peptide, melanin peptide, etc., reliable quality, inexpensive.

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hebei hongtan Biotechnology Co., Ltd