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Postion:Product Catalog >API>Circulatory system drugs>Angina Pectoris Drugs>Tetramethylpyrazine
Tetramethylpyrazine
  • Tetramethylpyrazine
  • Tetramethylpyrazine
  • Tetramethylpyrazine
  • Tetramethylpyrazine
  • Tetramethylpyrazine

Tetramethylpyrazine

Price $120
Package 1KG
Min. Order: 1KG
Supply Ability: 10 tons
Update Time: 2020-11-16

Product Details

Product Name: Tetramethylpyrazine CAS No.: 1124-11-4
EC-No.: 214-391-2 Min. Order: 1KG
Purity: 98% Supply Ability: 10 tons
Release date: 2020/11/16
Product Name: Tetramethylpyrazine
Synonyms: BS Factor;Ligustrazine;Pyrazine,tetramethyl-;Tetramethylpyrazin;tetramethyl-pyrazin;2,3,5,6-TETRAMETHYLPYRAZINE;2,3,5,6-TETRAMETHYLPYRAZINES;2,3,5,6-TETRAMETHYL-1,4-PYRAZINE
CAS: 1124-11-4
MF: C8H12N2
MW: 136.19
EINECS: 214-391-2
Product Categories: Pyrazine;Heterocyclic Compounds;Pyrazines;Mono- & Polyalkylpyrazines;pyrazine Flavor;Alphabetical Listings;Flavors and Fragrances;Q-Z;Certified Natural ProductsFlavors and Fragrances;Building Blocks;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File: 1124-11-4.mol
Article illustration
 
Tetramethylpyrazine Chemical Properties
Melting point  77-80 °C(lit.)
Boiling point  190 °C(lit.)
density  1.08
FEMA  3237
Fp  128-130°C/200mm
storage temp.  Store below +30°C.
solubility  4g/l
Water Solubility  Soluble in water (4 g/L at 20°C).
BRN  113100
Stability: Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference 1124-11-4(CAS DataBase Reference)
NIST Chemistry Reference Pyrazine, tetramethyl-(1124-11-4)
EPA Substance Registry System Pyrazine, tetramethyl-(1124-11-4)
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38
Safety Statements  26-39-24/25-37/39-36
WGK Germany  3
RTECS  UQ3905000
TSCA  Yes
HS Code  29339990
 
MSDS Information
 
 
Tetramethylpyrazine Usage And Synthesis
Description Tetramethylpyrazine (TMP) is a kind of alkaloids identified in Ligusticum wallichii FRANCH. It has various kinds of medical applications. It has long been used in China for the treatment of cardiovascular problems. It also has antiinflammatory and analgesic effect. It can be used for the treatment of diabetic peripheral neuropathy. Through effectively penetrating across the blood-brain barrier, it can exert its neuroprotection function which is useful for the treatment of ischemic brain injury. Moreover, it can eliminate superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.
Chemical Characteristic White crystal or powder. With aroma of beef and heated lard and fermented soybean flavor. It smells chocolate flavor when diluted to 20mg/kg. Boiling point is 190℃. Melting point is between 84 and 86℃. Soluble in ethanol, most non-volatile oils and propylene glycol, slightly soluble in water.
Natural products exist in guava, roast beef, cocoa, coffee, shrimp and so on.
Uses
  • Permissible edible flavors, mainly used to prepare meat, cocoa, peanut, nut, coffee, chocolate flavor and so on;
  • For medicine production;
  • Used as flavoring agents, sweeteners for alcoholic beverages, flavor and enriching supplement for cigarettes.
Preparation
  • Butanedione monoxime generated by butanone and ethyl nitrite condensation is reduced and cyclized to produce methylpyrazine. The cyclization reaction product is subjected to steam distillation and the distillate is cooled,crystallized and filtered to generate crude tetramethylpyrazine which is refined with water recrystallization and activated carbon to decolor. Ethanol solution with 15% to 20% hydrogen chloride can be added into acetone to prepare hydrochloride salt.
  • Condensed by 2,3-butanedione and 2,3-butanediamine.
References TH Tsai, CC Liang. International Journal of Pharmaceutics, 216. 1-2 (2001)
WU, Zhi-youg, et al. Chinese Journal of Experimental Traditional Medical Formulae 14 (2012): 085.
Ozaki, Yukihiro. Chemical and pharmaceutical bulletin 40.4 (1992): 954-956.
Kao, Tsung-Kuei, et al. Neurochemistry international 48.3 (2006): 166-176.
Zhang, Zhaohui, et al. Life sciences 72.22 (2003): 2465-2472.
Chemical Properties white crystals or powder
Uses Usually used in research and treatment of multiple disorders.
Definition ChEBI: A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
 
Tetramethylpyrazine Preparation Products And Raw materials
Raw materials Sodium nitrite-->2,3-Butanedione-->Acetylacetone-->1,4-DIAMINOBUTANE-->Ethyl nitrite-->2-Methylpyrazine

Company Profile Introduction

Longyan Tianhua Biological Technology Co., Ltd is located in Longyan city, Fujian Province, China. It is a large-scale high-tech integrated enterprise dedicated to the research, development and sales of fine chemicals, pharmaceutical raw material intermediates, food and feed additives. The company has its own research and development base, equipped with advanced production equipment and efficient and precise testing instruments, has set up a strict and scientific quality management system, and constantly committed to technological innovation, product innovation and management innovation, so as to ensure that our products have super competitiveness in the same industry.? Company's main: Phenformin Hydrochloride, Chlorhexidine Acetate, Indomethacin Biphenyl benzyl azole dyclonine hydrochloride clorprenaline hydrochloride griseofulvin chloramphenicol maleic acid to guangxi pp qi, fucus xanthine tert-butyl of hydroxy anisole (BHA), ammonia, benzene pteridine zonisamide moxifloxacin mother nucleus moxifloxacin side chain moxifloxacin hydrochloride clobetasol propionate tranexamic acid raw material, and so on.? The annual sales volume of the company is around 3 million DOLLARS. Its products have been sold to more than 40 countries and regions all over the world, and have been well received. Moreover, the buyback rate of customers is very high. Longyan Tianhua Biotechnology Co., LTD. Is looking forward to long-term cooperation with you.

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  • Since: 2019-10-11
  • Address: Room 201, 11 Xinhouying Road, Xicheng Lian, Xinluo District, Longyan City, Fujian Province, China
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