Product Details
| Product Name:
(-)-Blebbistatin |
CAS No.:
856925-71-8 |
| Min. Order:
1KG |
Purity:
95%~99.99% |
| Supply Ability:
10 MT/ Month |
Release date:
2021/01/06 |
Heidi 168
| (-)-Blebbistatin Basic information |
| Product Name: |
(-)-Blebbistatin |
| Synonyms: |
(-)-BLEBBISTATIN;4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-;(+/-)-BLEBBISTATIN;(S)-(-)-BLEBBISTATIN;(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem;(3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;CS-978;3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one (-)-Blebbistatin |
| CAS: |
856925-71-8 |
| MF: |
C18H16N2O2 |
| MW: |
292.336 |
| EINECS: |
|
| Product Categories: |
Caspases/Apoptosis;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: |
856925-71-8.mol |
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| |
| (-)-Blebbistatin Chemical Properties |
| Melting point |
210-212°C |
| Boiling point |
507.3±60.0 °C(Predicted) |
| density |
1.31±0.1 g/cm3(Predicted) |
| storage temp. |
Desiccate at +4°C |
| solubility |
DMSO: soluble5mg/mL |
| form |
Yellow solid |
| pka |
11.15±0.20(Predicted) |
| Hazard Codes |
Xn |
| Risk Statements |
20/21/22-36/37/38 |
| Safety Statements |
26-36/37 |
| WGK Germany |
3 |
| |
| (-)-Blebbistatin Usage And Synthesis |
| Chemical Properties |
Bright Yellow Solid |
| Uses |
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. [a]D= -103 |
| Biological Activity |
Selective inhibitor of myosin II ATPase activity (IC 50 ~0.5-5 μ M); active enantiomer of (±)-blebbistatin ((?-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one ). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells. |
Company Profile Introduction
Technology research and transfer of pilot screening, pilot scale-up and mass production solutions , for pharmaceutical intermediates, biologicals and fine chemicals (Not including inflammable , explosive , hazardous goods ) ; Market : Nano material , metal catalyst , raw material of cosmetics , pharmaceutical intermediates , chemicals , photoelectric material , import and export of technology and goods (For projects subject to approval according to law, business activities can be carried out only after approval by relevant departments ).
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