Progesterone

Product Name: Progesterone

Synonyms: PROGESTERONE-WATER SOLUBLE;progestin;PROGESTERONE;PRIMOLUT;Glanducorpin;Gynlutin;gynoluton;Gynolutone

CAS: 57-83-0

MF: C21H30O2

MW: 314.46

EINECS: 200-350-6

Progesterone Structure

Progesterone Chemical Properties

Melting point 128-132 °C(lit.)

alpha 186 º (c=1, ethanol)

Boiling point 394.13°C (rough estimate)

density d23 1.166; d20 1.171

refractive index 182 ° (C=2, Dioxane)

Fp 2℃

storage temp. Store at RT

solubility H2O: 25 mg/mL, may be clear to slightly hazy

form powder

color Yellow to yellow-brown

Water Solubility <0.1 g/100 mL at 19 ºC

Merck 7773

BRN 1915950

Stability: Stable. Incompatible with strong oxidizing agents.

Uses

The main physiological effects of progesterone:

1. Progesterone can maintain the female animal pregnancy, and cause a series of physiological changes, such as inhibition of female estrus.

2. Progesterone has the power to promote the thickening of the lining of the uterus, promote the bending of the gland and to increase secretion function.

3. Progesterone can inhibit the peristalsis of the uterus, and contribute to the cervix contraction, secretion of mucus, etc.. These physiological changes provide suitable environment for the operation, growth and development of early embryos, as well as the continued growth of the fetus.

4. Small amount of progesterone is also used in combination with the hormone estrogen to promote female estrus. The synergy between progesterone and prolactin can promote the development of mammary glands.

5. Progesterone is involved in the feedback regulation of the hypothalamus and anterior pituitary, which makes the balance of the animal reproductive hormones. In vivo, progesterone content of all sorts of livestock follicular phase is below 1 ng/ml, while in bovine corpus luteum period is approximately 4 ng/ml, pregnancy period is about 18 ng/ml.

6. Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.