CARBOXYMETHYL CHITOSAN

INCI Name: CARBOXYMETHYL CHITOSAN

Molecular Formula: C20H37N3O14

Molecular Weight: 543.52

Appearance: White fine powder

Purity: 98%

CAS NO.: 83512-85-0

EINECS No.: 695-802-6

Application: cosmetics and skin care products

Carboxymethyl chitosan in cell anti-inflammatory experiments,it can significantly reduce IL6 and TNFα levels.It also shows anti-inflammatory effects in human experiments; animal experiments promote skin stratum corneum Forming cell generation, accelerating the repair of the skin surface stratum corneum, indicating that it has a skin barrier repair function; it can quickly alleviate the itching of the skin caused by histamine, and significantly alleviate the tingling sensation caused by skin allergies. Animal experiments have confirmed its antipruritic effect.

Carboxymethyl chitosan is used as a film-forming agent and viscosity control in cosmetics.

1) Moisturizing mechanism

1. Rheological properties: the dissociation of the hydroxyl group makes the carboxymethyl chitosan molecules in the solution in a mutually exclusive state of negative ions, and the conformation is loose, which can occupy the entire solution space when the concentration is low; when the concentration is high, they are entangled to form a network. The structure gives the solution special rheological properties and has good film-forming properties. After being applied to the skin surface, it can form a layer of hydration film to maintain the moisturizing effect on the stratum corneum and prevent the skin from drying out.

2. Because carboxymethyl chitosan is highly stretched and intertwined to form a continuous network structure, water molecules are combined with each other through polar bonds and hydrogen bonds in this network, so that they can absorb and maintain them. Thousands of water of its own mass.

2) Anti-corrosion and synergistic mechanism

1. Under acidic conditions, the protonated ammonium in the MHA Plus molecule is positively charged, adsorbs negatively charged bacteria, attaches to the surface of the bacterial cell wall, interferes with the normal metabolism of cells, and inhibits bacterial reproduction.

2. After MHA Plus adsorbs bacteria, it penetrates the porous cell wall (mainly composed of chitin) and enters the bacterial cell. It may form a stable complex with DNA, interfere with the action of DNA polymerase or RNA polymerase, and hinder DNA or The synthesis of RNA inhibits the reproduction of bacteria.