Prilocaine

Prilocaine CAS 721-50-6 99% Purity

Product discription

Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.

Usage And Synthesis

It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.    

Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.    

In terms of pharmacological parameters, prilocaine is comparable to lidocaine; however, because of a number of toxic manifestations, it is rarely used in medical practice. Citanest and xylonest are well-known synonyms for prilocaine.    

Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.

Our Service

1.Cooperate with research institutions, we strictly control the process from raw material to finished product.

2.We can provide the reasonable price, high quality products and prompt shipment.

3.We can send the goods to your delivery address directly. It is relatively safe and fast. 

4.Quick and clear response to customers questions, we’ll treat every email and message within 24 hours usually much faster.

5.We can provide you a discount if you place a substantial order with us.

6.Products can be packaged and company logo can be customized according to customer requirements.

Our company

Guangzhou Biocar Biotechnology Co.,Ltd.,formerly known as Guangdong Yangye Pharmaceutical Factory established in 2005, which is affiliated to Wuhan Biocar Group. With the rise of Internet +, company's business process is accelerating. The company's board of directors has decided to establish Guangzhou Yangye Biotechnology Co., Ltd. at the end of 2016.
Guangzhou Biocar Biotechnology Co.,Ltd. is located near Zhujiang New Town, Tianhe District, one of the prosperous areas in Guangzhou. This helps facilitate business negotiations at home and abroad. It is a high-tech enterprise centered in Guangdong, radiating across our country and facing the world. And it is mainly engaged in the research, development and sales of new chemical raw materials, the custom synthesis and import and export of pharmaceutical intermediates and APIs, the agency sales of pharmaceutical chemicals, the research and development, production and sales of flavors, fragrances and chemical raw materials. Its factory covers an area of more than 4,000 acres and has more than 600 employees.
Guangzhou Biocar Biotechnology has a production base for deep processing of feed additives and veterinary drug intermediates based on main pharmaceutical intermediates.
It has always adhered to the tenet of "Being faithful, cultivating harmony and achieving win-win cooperation" and treats every customer sincerely.
We are looking forward to cooperating with you sincerely, and making mutual benefit and brilliance!

Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitateyou track the express
FAQ
Q1: Can i get some samples?
A: Yes, we can supply the sample, but the shipping cost be paid by ourcustomers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosedour bank information. Payment by T/T, Western Union or Paypal.
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay theshipping cost or arrange a courier to us and take the samples. You cansend us your product specifications and requests,we will manufacture theproducts according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g onthe condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chineseholiday not included)
Q6: Do You Ship Over The Weekend?
We use EMS,TNT,FEDEX,DHL four kinds of couriers. EMS don't collected parcelsover the weekend. The packages can be shipped out normally before 12:00a.m in Beijing time if you choose to ship by TNT or FedEx.

Transaction requirements: serious and sincere, pragmatic and efficient
1. We support the verification of the authenticity of our warehouse andproducts through video conversations.
2. If we release this product, it means that we can also produce its similarproducts.
3. We have insured each product, if the goods are lost or damaged, wecan provide a 100% refund.
4. Delivery time limit: 4-7 days in the UK, 10-15 days in other countries.
5. Company qualification: Seven years since its establishment, with 2factories and 8 laboratories,has cooperated with Wuhan Textile Universityand set up a talent reserve base, which can accept the customization ofpharmaceutical intermediates and the mass production of large chemicals.
6. Quality inspection certificate: every product has its third-party qualityinspection certificate to ensure the safety of the product.
7. Advantages: can be customized production, can be shipped in batches,price concessions, high timeliness.
8.Can assist customers in brand design and printing, and has successfullybuilt OMEGA, ZE and other brands
9. Payment method: Western Union, MoneyGram, Bitcoin, bank transfer, remitlyare currently accepted.
10.Reject malicious inquiries, reject scammers
11.Provide door-to-door transportation, as well as normal customs clearanceservices