3-Amino-4-phenylbutyric acid hydrochloride

Phenibut is a non-prescription pharmaceutical that is actually a GABA molecule with the addition of a phenyl group. Researchers discovered that by changing GABA into 4-Amino-3-Phenylbutyric Acid, it was able to cross more easily into the nervous system & across the blood-brain barrier. Since it is a GABA, an inhibitory neurotransmitter, derivative, Phenibut increases GABA levels.Phenibut is a white crystalline powder and the taste is very sour. It is readily soluble in water, soluble in alcohol, and the pH of a 2.5% water solution is between about 2.3 and 2.7.

Function

1. Phenibut is used by bodybuilders to reduce fatigue and improve neurological functions.
2. Phenibut has been and is still used medically to treat stress, relieve tension, improve sleep, and as a potentiate for other medications.
3. Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA.

Application

Phenibut is a central depressant and analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), or a GABA analogue. The addition of a phenyl ring allows phenibut to cross the blood-brain barrier. Phenibut was developed in the Soviet Union in the 1960s, and has since been used there as a pharmaceutical drug to treat a wide range of ailments, including posttraumatic stress disorder, anxiety, depression, asthenia, insomnia, alcoholism, stuttering, and vestibular disorders, and other conditions.
Phenibut is a close structural analogue of GABA, as well as of baclofen (β-(4-chlorophenyl)-GABA) and GABOB (β-hydroxy-GABA). Phenibut is believed to act as a selective GABAB receptor agonist; studies are conflicting as to whether phenibut also acts as a GABAA receptor agonist. More recently, phenibut has been found to act preferentially as a blocker of α2δ subunit-containing voltage-gated calcium channels, similarly to gabapentin. As such, by definition, phenibut is a gabapentinoid. 

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