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Postion:Product Catalog >Chemical Reagents>Organic reagents>Sulfonyl halide>4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
  • 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
  • 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
  • 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
  • 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
  • 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride NEW

Price Get Latest Price
Package 1KG 5KG 25KG
Min. Order: 1KG
Supply Ability: 20 T each week
Update Time: 2023-08-13

Product Details

Product Name: 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride CAS No.: 30827-99-7
EC-No.: 608-547-2 Min. Order: 1KG
Purity: 98%~99% Supply Ability: 20 T each week
Release date: 2023/08/13

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Product Name:4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
Synonyms:4-(Fluorosulphonyl)phenethylamine hydrochloride, 2-[4-(Fluorosulphonyl)phenyl]ethylamine hydrochloride, AEBSF;Benzenesulfonyl fluoride, 4-(2-aMinoethyl)-, hydrochloride (1:1);4-(2-AMinoethyl)benzenesulfonyl fluoride hydrochlorid;4-(2-Aminoethyl)-benzenesulfonyl fluoride hydrochloride (1:1);BROMOPHENOL BLUE NA SALT PROTEOMICS GR;AEBSF HCI;AEBSF;AEBSF HCL
CAS:30827-99-7
MF:C8H11ClFNO2S
MW:239.69
EINECS:608-547-2
Product Categories:ProteaseInhibitors;inhibitor;Inhibitors
Mol File:30827-99-7.mol
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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Chemical Properties
Melting point 175-177 °C
storage temp. 2-8°C
solubility H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
form Powder
color White
PHpH3.0~5.0 (10g/L, 25℃)
Water Solubility 10 g/L (20 ºC)
Sensitive Moisture Sensitive
BRN 7604627
Stability:Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
InChIKeyWRDABNWSWOHGMS-UHFFFAOYSA-N
CAS DataBase Reference30827-99-7(CAS DataBase Reference)

Safety Information
Hazard Codes C,Xi
Risk Statements 34-36/37/38
Safety Statements 45-36/37/39-26-36
RIDADR UN 3261
WGK Germany 3
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29214990


4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Usage And Synthesis
DescriptionAEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
Chemical Propertieswhite powder
UsesAEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
UsesRecommended concentrations for use are 0.1-1 mM.
General DescriptionPefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.
Biochem/physiol ActionsIrreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25?mM.
storageStore at -20°C
References1) Powers?et al. (2002),?Irreversible inhibitors of serine, cysteine and threonine proteases; Chem. Rev.,?102?4639 2) Diatchuk?et al.?(1997),?Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds; J. Biol. Chem.,?272?13292

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