CAS 317318-84-6 Gw-0742

99% Purity Sarms Powder CAS 317318-84-6 Gw-0742 Gw610742 Light Yellow Powder


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Product Description:

1.GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI.
Reference
Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Salvatore Cuzzocrea. GW0742, a selective PPAR-β/δ agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. August 2010. Journal of Leukocyte Biology. vol. 88 no. 2 291-301
Caroline I. Schnegg, Dana Greene-Schloesser, Mitra Kooshki, Valerie S. Payne, Fang-Chi Hsud, Mike E. Robbins. hippocampal-dependent cognitive impairment after whole-brain irradiation. Free Radical Biology and Medicine. Volume 61, August 2013, Pages 1-9.

How SR9009 works:

By binding and activating the Rev-Erb protein, Stenabolic triggers a very wide range of processes in the body. The most prominent being the increase of mitochondria count in the muscles and an enhanced metabolism.

As a consequence of the increased number of mitochondria in the muscles, the user will notice a drastic improvement in endurance and muscle strength. In fact, the mice used in studies could run 50% more when they were administered with SR9009, both in terms of distance and time. This is possible due to the fact that these mitochondria are precisely the ones generating energy in the body. Besides, thanks to the increase in number of macrophages, defective mitochondria are removed from the muscles and replaced with new ones.

Furthermore, the change in metabolic rates increases energy expenditure by 5% even when the user is resting; hence, SR burns excess calories and doesn't allow them to convert into fat. This, coupled with enhanced metabolism of glucose, helps effectively burn fat, which makes the body act is if it were in a constant state of exercise.