S-4
Price | $10 |
Package | 1KG |
Min. Order: | 10G |
Supply Ability: | 1000kg |
Update Time: | 2018-10-22 |
Product Details
Product Name: S-4 | CAS No.: 401900-40-1 |
Min. Order: 10G | Purity: 99% |
Supply Ability: 1000kg | Release date: 2018/10/22 |
Andarine Basic information |
Biological activity In vitro In vivo Characteristics |
Product Name: | Andarine |
Synonyms: | S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide;N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide;Ostarine;(2R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;MK-2866;Andarine;Propanamide,3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phe nyl]-,(2S)-;sarM s4 |
CAS: | 401900-40-1 |
MF: | C19H18F3N3O6 |
MW: | 441.36 |
EINECS: | 1308068-626-2 |
Product Categories: | APIs;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;SARMS;Inhibitors |
Mol File: | 401900-40-1.mol |
Andarine Chemical Properties |
Melting point | 70-74℃ |
density | 1.47 |
storage temp. | Refrigerator |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36 |
Safety Statements | 26 |
MSDS Information |
Andarine Usage And Synthesis |
Biological activity | Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3. |
In vitro | In vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%. |
In vivo | In vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%. |
Characteristics | Andarine is a selective non-steroidal androgen receptor (AR) agonist. |
Chemical Properties | Pale Yellow Solid |
Uses | It is a potent and tissue-selective androgen receptor modulator (SARM) |
How is the quality |
The qualities of most products are above 99% purity, same are 99.5% purity. |
2, How is the package |
Foil bag or as customer's required. |
3, How is the storage |
Keep in dry and cool place. |
4, Do I need to pay extra for shipping cost |
No, our price includes the shipping cost already; you need not pay for any tax and others. |
5, Can I order sample to test |
Yes, you are welcome to order sample before placing bulk order. We will send the sample directly to your door by courier. |
6, minimum quantity |
Usually our minimum quantity is 10g. But you are welcome to order samples to check the quality and our service. |
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