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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Endocrinology & Hormones>Androgen Receptor agonists>S-4
S-4
  • S-4
  • S-4
  • S-4
  • S-4
  • S-4

S-4

Price $10
Package 1KG
Min. Order: 10G
Supply Ability: 1000kg
Update Time: 2018-10-22

Product Details

Product Name: S-4 CAS No.: 401900-40-1
Min. Order: 10G Purity: 99%
Supply Ability: 1000kg Release date: 2018/10/22
Andarine Basic information
Biological activity In vitro In vivo Characteristics
Product Name: Andarine
Synonyms: S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide;N-[4-Nitro-3-(trifluoromethyl)phenyl]-(2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methylpropanamide;Ostarine;(2R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide;MK-2866;Andarine;Propanamide,3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phe nyl]-,(2S)-;sarM s4
CAS: 401900-40-1
MF: C19H18F3N3O6
MW: 441.36
EINECS: 1308068-626-2
Product Categories: APIs;Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;SARMS;Inhibitors
Mol File: 401900-40-1.mol
Article illustration
 
Andarine Chemical Properties
Melting point  70-74℃
density  1.47
storage temp.  Refrigerator
 
Safety Information
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
MSDS Information
 
 
Andarine Usage And Synthesis
Biological activity Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. Phase 3.
In vitro In vitro, Andarine binds to androgen receptors with high affinity with Ki of 4 nM. Moreover, 10 nM Andarine stimulated the transcription adjusted by androgen receptor, up to 93%.
In vivo In vivo, Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.
Characteristics Andarine is a selective non-steroidal androgen receptor (AR) agonist.
Chemical Properties Pale Yellow Solid
Uses It is a potent and tissue-selective androgen receptor modulator (SARM)
 

How is the quality

The qualities of most products are above 99% purity, same are 99.5% purity.

2, How is the package

Foil bag or as customer's required.

3, How is the storage

Keep in dry and cool place.

4, Do I need to pay extra for shipping cost

No, our price includes the shipping cost already; you need not pay for any tax and others.

5, Can I order sample to test

Yes, you are welcome to order sample before placing bulk order. We will send the sample directly to your door by courier.

6, minimum quantity

Usually our minimum quantity is 10g. But you are welcome to order samples to check the quality and our service.

 

 Article illustrationArticle illustrationArticle illustrationArticle illustrationArticle illustration

Company Profile Introduction

Meihua Biological Technology Co.,Ltd, is a global trading company, has been focusing on developing and manufacturing of advanced fine chemical and multiple intermediates. we are all members devoted to working in the filed for seven years. Rich experience gives us great enlightenments in founding of enterprise Meihua Biological Technology Co.,Ltd ,was established on the ground in 2011, is a collection, production, assay and sales into an integrated trading company in one of professional service and exported enterprise. As a mature manufacture, we have rigorous process flow. All final products come to us only by passing HPLC or GC assay. Through 30 procedures in all, we concentrate on every one gram of quality and every one milliliter of purity to your trust. We customize organic material,biochemical reagents,fine chemicals, pharmaceutical intermediates, OLED intermediates, liquid crystal intermediates and glucosides for customers, with high quality, competitive price, professional service and reliable source, and hundreds of species to choose. Such as 4-MPD/5F-ADB/2F-DCK/BK-EBDP/FUB-AMB/ADBF and so on, and new productions including 4433-77-6(BMK)/13605-48-6(PMK)16648-44-5(Benzeneacetic Acid ) etc. Of course, we support various transportation and safe payment. We are aiming at becoming a leading manufacture and trading company in China, even global. We are looking forward to establishing long-term cooperation relationship with customers in the word. We sincerely welcome to contact with us. For more information, please visit our website at http://www.hbmeihua.cn/

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