Valsartan

Price	$100
Package	25KG

Product Details

Product Name: Valsartan	CAS No.: 137862-53-4
EC-No.: 1592732-453-0	Min. Order: 1KG
Purity: 99%	Supply Ability: customise
Release date: 2019/07/06
Product Number：: WM188

Product Name:	Valsartan
Synonyms:	L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;Ambroxol Hydrochloride Imp.D;3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic aci;(S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]amine;(S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic aci;VALSARTAN IMP C;Valsartan,99%e.e.;N-(1-OXOPENTYL)-N-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-L-VALINE
CAS:	137862-53-4
MF:	C24H29N5O3
MW:	435.52
EINECS:	1592732-453-0
Product Categories:	Inhibitors;Active Pharmaceutical Ingredients;Antihypertensive;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Aromatics;Chiral Reagents;Heterocycles;API Reference Standard Free Base API;DIOVAN
Mol File:	137862-53-4.mol

Valsartan Chemical Properties

Melting point	116-117°C
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO: ≥20mg/mL
color	white to tan
Merck	14,9916
Stability:	Hygroscopic
InChIKey	ACWBQPMHZXGDFX-QFIPXVFZSA-N
CAS DataBase Reference	137862-53-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
RTECS	YV9455000
Hazardous Substances Data	137862-53-4(Hazardous Substances Data)

MSDS Information

Provider	Language
3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid	English

Valsartan Usage And Synthesis

Indications and Usage	Valsartan is a type of specific angiotensin I (AT1) receptor antagonist and a clinical non-dermal AT1 receptor antagonist following losartan that has important effects in adjusting bodily blood pressure and maintaining electrolyte-body fluid balance. Valsartan’s antihypertensive effects are stronger than those of enalapril and is suitable for treating hypertension, mild to moderate primary hypertension, and especially secondary hypertension caused by renal damage. It can significantly reduce proteinuria for hypertension patients with diabetes or normal liver functions, and it can promote uric acid and urinary sodium to protect the kidney. Valsartan is also suitable for reducing the cardiovascular mortality for high risk patients (left ventricular failure or dysfunction) after experiencing a heart attack.
Mechanisms of Action	Valsartan selectively affects the AT1 receptor subtype and prevents AT1 from binding with AT1 receptors (its selective AT1 receptor antagonizing effect is about 20000 times greater than its effects on AT2 receptors), thus inhibiting vasoconstriction and aldosterone release, producing an antihypertensive effect, but it cannot inhibit the release of aldosterone caused by potassium ions (K+). Valsartan does not affect angiotensin-converting enzymes (ACE) or renin and its receptors, and it does not inhibit ion channels related to blood pressure regulation and sodium balance. Valsartan does not inhibit ACE and does not affect bodily bradykinin levels, thus causing less coughing side effects than ACE inhibitors. Valsartan does not affect heart rate when lowering blood pressure. Sudden ceasing in Valsartan use will not cause rebound hypertension or other side effects. Valsartan does not affect hypertension patients’ overall cholesterol, triglyceride, blood glucose, or uric acid levels.
Pharmacokinetics	For most patients, a single oral dose will have antihypertensive effects that occur within 2 hours, peak at 4-6 hours, and continue for over 24 hours. 2-4 weeks of treatment will result in maximum hypertensive curative effects, which will last throughout long-term treatment. It can be used with thiazide diuretics to further strengthen antihypertensive effects.
Clinical Research	A clinical trial showed that Valsartan has very noticeable effects on mild to moderate hypertension. A daily dose of ≥80 mg can effectively control systolic and diastolic blood pressure while not affecting blood pressure’s circadian rhythm; a daily 160mg dose has more noticeable effects than a daily 100mg dose of losartan. Moderate hypertension patients with intact renal functions have a good tolerance towards Valsartan, Valsartan’s curative effects are significantly superior to those of ACE inhibitors, and there are minimal adverse reactions. Effective in treating severe hypertension when combined with other antihypertensive drugs.
Chemical Properties	White Crystalline Powder
Uses	A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Uses	Angiotensin II inhibitor, antihypertensive
Uses	May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second l
Definition	ChEBI: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

Recommended supplier

Product name	Price		Suppliers	Update time
Valsartan	$46.00/10mg	VIP5Y	TargetMol Chemicals Inc.	2024-11-04
Valsartan	$0.00/1g	VIP1Y	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	2024-10-09
Valsartan	$10.70/1KG	VIP4Y	Hebei Chuanghai Biotechnology Co,.LTD	2024-08-21
Valsartan	$0.10/1KG	VIP5Y	Shaanxi Dideu Medichem Co. Ltd	2024-08-21
Valsartan	$999.00/5kg	VIP1Y	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	2024-08-09
Valsartan	$0.00/1Kg/Bag	VIP4Y	Sinoway Industrial co., ltd.	2024-06-27
Valsartan	$0.00/1KG	VIP1Y	Hangzhou Hyper Chemicals Limited	2024-06-06
Valsartan	$0.00/1kg	VIP1Y	Shaanxi TNJONE Pharmaceutical Co., Ltd	2024-05-08
Valsartan	$15.00/1kg		Ouhuang Engineering Materials (Hubei) Co., Ltd	2024-04-29
Valsartan	$35.00/1kg	VIP1Y	Sigma Audley	2024-03-14

Min. Order:	1KG
Supply Ability:	customise
Update Time:	2019-07-06

Product Details

Company Profile Introduction

You may like

Recommended supplier

career henan chemical co