Lubiprostone
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | 1 |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Lubiprostone | CAS No.: 136790-76-6 |
| Min. Order: 1KG | Purity: 98% |
| Supply Ability: 1 | Release date: 2019/07/06 |
CR368
| Product Name: | Lubiprostone |
| Synonyms: | Lubiprostone API;7-[(1r,4r,6r,9r)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]heptanoic acid;lubiprostone;(11a)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Ru 0211;C13707;(11α)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α)- |
| CAS: | 136790-76-6 |
| MF: | C20H32F2O5 |
| MW: | 390.4618864 |
| EINECS: | |
| Product Categories: | Inhibitors;Prostaglandin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs |
| Mol File: | 136790-76-6.mol |
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| Lubiprostone Chemical Properties |
| Melting point | 56-59°C |
| storage temp. | -20°C Freezer |
| Safety Information |
| MSDS Information |
| Lubiprostone Usage And Synthesis |
| Description | Marketed under the trade name Amitiza, Lubiprostone is a chloride channel activator which is mainly used for the treatment of idiopathic (due to an unknown cause) chronic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is an oral medication approved by the FDA in January 2006. The mechanism of action of lubiprostone is the same as chloride channel activator. It functions by binding and activating ClC-2 chloride channels in the apical membrane of the gastrointestinal epithelium, which produces an efflux of chloride-rich fluid secretion. The increased amounts of secretions are effective to soften the stool, increase motility, promote spontaneous bowel movements (SBM), and speed up transit of stool in the colon. Therefore, the relevant symptoms, such as abdominal pain and bloating, can be reduced. |
| References | https://en.wikipedia.org/wiki/Lubiprostone http://www.medicinenet.com/lubiprostone/article.htm https://www.drugbank.ca/drugs/DB01046 https://pubchem.ncbi.nlm.nih.gov/compound/157920#section=Top |
| Chemical Properties | White Solid |
| Uses | A locally acting chloride channel activator for the treatment of gastrointestinal disorders |
| Uses | Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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杨俊青
sales@coreychem.com
sales@coreychem.com