Eplerenone
| Price | $1 |
| Package | 1KG |
| Min. Order: | 1G |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Eplerenone | CAS No.: 107724-20-9 |
| Min. Order: 1G | Purity: 98% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
AD68
| Eplerenone Basic information |
| Overview Chemical properties Mechanism of action Adverse effects References |
| Product Name: | Eplerenone |
| Synonyms: | pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;EPLERENONE 98%;EPLERENONE USP STANDARD;Elperenone;EplerenoneC24H3006;pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7 α, 11 α, 17 α);EPLERENONE AND N-1 INTERMEDIATE;epoxymexrenone |
| CAS: | 107724-20-9 |
| MF: | C24H30O6 |
| MW: | 414.49 |
| EINECS: | 1308068-626-2 |
| Product Categories: | Antihypertensive;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;Inspra;Cardiovascular APIs |
| Mol File: | 107724-20-9.mol |
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| Eplerenone Chemical Properties |
| Melting point | 241-243°C |
| alpha | D +5° (c = 0.437 in chloroform) |
| storage temp. | Store at RT |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| color | white to beige |
| λmax | 240nm(lit.) |
| Merck | 14,3625 |
| InChIKey | UZZAHAKTLYRDOK-MGIDJNSKSA-N |
| Safety Information |
| RIDADR | 3077 |
| Hazardous Substances Data | 107724-20-9(Hazardous Substances Data) |
| MSDS Information |
| Eplerenone Usage And Synthesis |
| Overview | Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It can be used individually or in combination with other medications to treat hypertension by blocking the action of aldosterone, a natural substance in the body that raises blood pressure. |
| Chemical properties | Eplerenone is an odorless, white to off-white crystalline powder. It is very slightly soluble in water, with its solubility essentially pH-independent. The octanol/water partition coefficient of eplerenone is approximately 7.1 at pH 7.0. |
| Mechanism of action | Aldosterone,with many physiological and pathological effects, can cause central blood pressure and endothelial injury (catecholamines enhance its role), reduce heart rate variability, induce ventricular arrhythmias, and promote retention of sodium, potassium and magnesium loss, promote myocardial fibrosis, necrosis and inflammation, damage the fibrinolytic system. Angiotensin converting enzyme inhibitors (also called angiotensin converting enzyme inhibitors, referred to as ACEI) and angiotensin Ⅱ receptor antagonist ARB aldosterone can inhibit the secretion of adrenaline, but after a period of treatment.The release of aldosterone was restored,which may even exceed the baseline plasma concentration levels. Despite adequate treatment of ACEI and ARB, aldosterone-induced damage can still happen, so it is necessary to use aldosterone receptor antagonists in the treatment of hypertension. Clinical studies have shown that patients who are not satisfied with the efficacy of ACEI or ARB therapy can add eplerenone along with the treatment. Non-selective aldosterone receptor antagonist spironolactone can reduce mortality in patients with congestive heart failure, However, the side effects of male hyperplasia and other diseases associated with sex hormones have limited its application in the treatment of hypertension. |
| Adverse effects | Common adverse drug reactions (ADRs) associated with the use of eplerenone include: hyperkalaemia, hypotension, dizziness, altered renal function, and increased creatinine concentration. |
| References | https://en.wikipedia.org/wiki/Eplerenone https://medlineplus.gov/druginfo/meds/a603004.html http://www.rxlist.com/inspra-drug.htm |
| Chemical Properties | White Solid |
| Uses | Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure. |
| Uses | Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor and is sp |
| Uses | anticancer agent |
| Biological Activity | Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo . |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY
杨俊青
sales@coreychem.com
sales@coreychem.com