Product Details
Product Name:
Rosiglitazone maleate |
CAS No.:
155141-29-0 |
Min. Order:
1G |
Purity:
98% |
Supply Ability:
100KG |
Release date:
2019/07/06 |
AD68
Rosiglitazone maleate Basic information |
Product Name: |
Rosiglitazone maleate |
Synonyms: |
5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE;5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate;ROSIGLITAZONE MALEATE;RosiglitazoneTartrate;Avandi;BRL-49653c;RSIGLITAZONEMALEATE;5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate |
CAS: |
155141-29-0 |
MF: |
C22H23N3O7S |
MW: |
473.5 |
EINECS: |
1312995-182-4 |
Product Categories: |
Active Pharmaceutical Ingredients;Antidiabetic;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Rosiglitazone;Heterocycles;Sulfur & Selenium Compounds;Inhibitor;API |
Mol File: |
155141-29-0.mol |
![Article illustration](https://www.chemicalbook.com/CAS/GIF/155141-29-0.gif) |
|
Rosiglitazone maleate Chemical Properties |
Melting point |
235-240°C |
storage temp. |
-20°C Freezer |
pka |
6.1; 6.8(at 25℃) |
CAS DataBase Reference |
155141-29-0(CAS DataBase Reference) |
Hazard Codes |
Xi |
Risk Statements |
20/21/22-36/38 |
Safety Statements |
24/25-37/39-26 |
|
Rosiglitazone maleate Usage And Synthesis |
Chemical Properties |
White To Off-White Solid |
Uses |
Insulin sensitizer; binds to peroxisome proliferator activated receptor gamma (PPAR- γ). |
Uses |
Thiazole alkanes antidiabetic drug |
Uses |
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. Rosiglitazone is a prototypical TZD that has served as a reference compound for this class. It is a potent and selective PPARγ ligand that binds to the PPARγ ligand-binding domain with a Kd value of 43 nM. It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively. Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of type 2 diabetes in humans for many years.[Cayman Chemical] |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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