Phenylbutazone

Price	$1
Package	1KG

Product Details

Product Name: Phenylbutazone	CAS No.: 50-33-9
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

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Product Name:	Phenylbutazone
Synonyms:	PHENYLBUTAZONE;1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline;1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine;1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine;1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione;3,5-dioxe-4buty-1,diphenyl-pyrazolidine;3,5-dioxo01,2-diphenyl-4-m-butyl-pyrazolidine;3,5-Dioxo-1,2-diphenyl-4-N-butyl-pyrazolidin
CAS:	50-33-9
MF:	C19H20N2O2
MW:	308.37
EINECS:	200-029-0
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Inhibitors;API;AZOLID
Mol File:	50-33-9.mol

Phenylbutazone Chemical Properties

Melting point	104-107 °C
Boiling point	448.76°C (rough estimate)
density	1.1591 (rough estimate)
refractive index	1.6140 (estimate)
storage temp.	-20°C Freezer
form	Powder
pka	4.5(at 25℃)
color	White to almost white
Water Solubility	<0.1 g/100 mL at 23.5 ºC
Merck	14,7277
BRN	290080
Stability:	Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
InChIKey	VYMDGNCVAMGZFE-UHFFFAOYSA-N
CAS DataBase Reference	50-33-9(CAS DataBase Reference)
NIST Chemistry Reference	Phenylbutazone(50-33-9)
EPA Substance Registry System	3,5-Pyrazolidinedione, 4-butyl-1,2-diphenyl-(50-33-9)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	36/37/38-20/21/22-42/43-45-36-11
Safety Statements	36/37/39-26-45-22-53-36/37-16
RIDADR	3249
RTECS	UQ8225000
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
Hazardous Substances Data	50-33-9(Hazardous Substances Data)

Phenylbutazone Usage And Synthesis

Abstract	Phenylbutazone, often referred to as "bute,"is a nonsteroidal anti-inflammatory, antipyretic, and analgesic drug (NSAID) for the short-term treatment of pain and fever results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis. Phenylbutazone has been removed from the United States market due to the availability of newer drugs with less adverse effects. Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, including injury, menstrual cramps, arthritis and other musculoskeletal conditions.
Chemical Property	It is soluble in acetone, chloroform or benzene freely; soluble in ethanol or ether; hardly soluble in water; soluble in sodium hydroxide solution.
Mechanism of action	Recent studies have found that the generating mechanism from phenylbutazone anti-inflammatory, analgesic and anti-rheumatic effect is not due to pituitary-adrenal excitement may be due to drugs that inhibit the generation of inflammatory tissue inflammation related active substances, such as synthesis of prostaglandins, white blood cells activities and transfer, release and activity of lysosomal enzymes; pain may also inhibit prostaglandin synthesis results.
Pharmacokinetic Study	Oral absorption effect is quickly and completely, reached the peak plasma concentration after about 2 hours. Plasma protein binding rate is 98%. The apparent volume of distribution is 0.12L/kg, such as increasing the dose, volume of distribution has also increased, but the blood concentration does not increase. Therefore, when using repeatedly, the steady-state plasma concentration does not increase linearly. The half-life is 56 to 86 hours. It can cross the placenta into the milk. This product is metabolized by the liver, metabolites is hydroxy phenylbutazone and γ-hydroxy phenylbutazone, still active, The final metabolites are excreted in urine and a small amount of bile is excreted through the urine.
Attention and Taboo	The side effects of phenylbutazone incidence rate is about 10%~20%, gastrointestinal irritation can cause nausea, vomiting, abdominal pain, constipation, overdose can cause peptic ulcer, blood in the stool. Damages also occur in other systems, such as rash, dizziness, hematuria, hepatitis, etc. Inhibit the bone marrow caused by neutropenia, or even aplastic anemia, such as the timely withdrawal is more recoverable and therefore should be ground check blood, no effect by 1 week, should not be reused. And double coumarin anticoagulants, sulfonamides, tolbutamide hypoglycemic drugs, increase the plasma concentration, toxicity increases. Sodium, chlorine retention effect, hypertension, edema, heart failure patients cannot use it and limit salt intake during the treatment. Patients with weak liver, osteoporosis, and kidney as well as drug allergy history are contraindicated or appropriate caution.
Preparation	Cyclization reaction of hydrogenated azobenzene and diethylmalonic acid diethyl: hydrazobenzene, butyl diethyl malonate, sodium sulfite and methanol are heated with severe reflux 1.5h, born in Bute salt, acidified with acetic acid to give Bute.
Acute toxicity	oral-rat LD50: 245 mg/kg; Oral-Mouse LD50: 270 mg/kg Irritation Data: Eye – rabbit, 100 mg, moderate
Flammability hazard properties	thermal decomposition emitted poisonous nitrogen oxides fumes
Storage characteristics	Treasury ventilation low-temperature drying; and food raw materials stored separately
Extinguishing agent	Water, carbon dioxide, dry powder, foam

Chemical Properties	Off-Whtie Solid
Uses	For the treatment of backache and ankylosing spondylitis
Uses	An inhibitor of Cox.
Uses	A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase
Uses	Phenylbutazone, a nonsteroidal anti-inflammatory drug, is an efficient reducing cofactor for the peroxidase activity of COX. Phenylbutazone-dependent inactivation of COX and prostacyclin synthase is markedly increased in the presence of 100 μM hydrogen peroxide with half-maximal effects at Phenylbutazone concentrations of 100 and 25 μM for COX and prostacyclin synthase, respectively.
General Description	Odorless white or off-white crystalline powder. Tasteless at first, but slightly bitter aftertaste. pH (aqueous solution) 8.2.
Air & Water Reactions	Phenylbutazone is relatively stable at ambient temperatures. Aqueous decomposition of Phenylbutazone occurs by hydrolysis and oxidation. Insoluble in water.
Reactivity Profile	Phenylbutazone is incompatible with strong oxidizers, strong acids and strong bases. .
Fire Hazard	Flash point data for Phenylbutazone are not available; however, Phenylbutazone is probably combustible.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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career henan chemical co