Amstat

Price	$1
Package	1KG

Min. Order:	1G
Supply Ability:	100KG
Update Time:	2019-07-06

Product Details

Product Name: Amstat	CAS No.: 1197-18-8
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

AD68

Amstat Basic information

Properties Coagulation and hemostasis drugs Indications Mechanism of action Pharmacokinetics Side effects

Product Name:	Amstat
Synonyms:	TIMTEC-BB SBB006715;TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID;trans-4-aminomethylcyclohexane-1-carboxylate;TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID;TRANEXAMIC ACID;amstat;amcha;amikapron
CAS:	1197-18-8
MF:	C8H15NO2
MW:	157.21
EINECS:	214-818-2
Product Categories:	4-Substituted Cyclohexanecarboxylic Acids;API's;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;API;CYKLOKAPRON;Cosmetics;Hemostatic;Pharmaceutical raw materials;Pharmaceutical intermediates
Mol File:	1197-18-8.mol

Amstat Chemical Properties

Melting point	>300 °C(lit.)
Boiling point	281.88°C (rough estimate)
density	1.0806 (rough estimate)
refractive index	1.4186 (estimate)
storage temp.	Store at 0°C
form	Crystalline Powder
color	White
Water Solubility	1g/6ml
Merck	14,9569
BRN	2207452
InChIKey	GYDJEQRTZSCIOI-LJGSYFOKSA-N

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	2
RTECS	GU8400000
HazardClass	IRRITANT
Toxicity	LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)

Amstat Usage And Synthesis

Properties

Amstat is an antifibrinolytic drug, commonly called Tranexamic acid. Tranexamic acid is a white crystalline powder. It is freely soluble in water and in glacial acetic acid and is very slightly soluble in ethanol and practically insoluble in ether.

Coagulation and hemostasis drugs

Tranexamic acid is a derivative of aminomethylbenzoic acid, and a kind of antifibrinolytic drugs to stop bleeding. The hemostasis mechanism of tranexamic acid is similar to aminocaproic acid and aminomethylbenzoic acid, but the effect is stronger. The strength is 7 to 10 times of aminocaproic acid, 2 times of aminomethylbenzoic acid, but toxicity is similar.
The chemical structure of tranexamic acid is similar to lysine, competitive inhibition of plasmin original in fibrin adsorption, to prevent their activation, protection fiber protein not to degrade by plasmin and dissolve, eventually achieve hemostasis. Applicable in the treatment of acute or chronic, localized or systemic primary fiber fibrinolytic hyperthyroidism caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hemorrhage of hypertrophy of the prostate, hemophilia, pulmonary tuberculosis hemoptysis, stomach bleeding, after operation of liver, lung, spleen and other viscera hemorrhage; also can be used in surgery when abnormal bleeding etc..
Clinical tranexamic acid has effect significantly to insect bites disease, dermatitis and eczema, simple purpura, chronic urticaria, artificial sex urticaria, toxic eruption and eruption. And also has a certain effect on erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles and alopecia areata. Treatment of hereditary angioedema effect is also good. In the treatment of Chloasma, general medicine is effective about 3 weeks, markedly effective 5 weeks, a course of 60 days. Given orally in doses of 0.25 ~ 0.5 g, a day 3 ~ 4 times. A few patients can nausea, fatigue, pruritus, abdominal discomfort, and diarrhea side effects after withdrawal symptoms disappear.

Indications

Various bleedings caused by acute or chronic, localized or systemic primary hyperfibrinolysis; secondary hyperfibrinolytic state caused by disseminated intravascular coagulation. Generally do not use this product before heparinization.
Trauma or surgical bleeding in tissue and organs with abundant plasminogen activators such as prostate, urethra, lung, brain, uterus, adrenal glands, and thyroid.
An antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase.
Fibrinolytic hemorrhage caused by artificial abortion, early placental detachment, stillbirth and amniotic fluid embolism; and increased menorrhagia caused by pathological intrauterine fibrinolysis.
Cerebral neuropathy mild bleeding, such as subarachnoid hemorrhage and intracranial aneurysm hemorrhage, the effect of Amstat in this condition is better than that of other anti-fibrinolytic agents. Special attention must be paid to the risk of cerebral edema or cerebral infarction. For severe patients with surgical indications, this product can only be used as an adjuvant drug.
For the treatment of hereditary angioneurotic edema, it can reduce the number and severity of episodes.
Used in patients with hemophilia for their active hemorrhage in combination with others drug.
Hemophilia patients with factor VIII or factor IX deficiency in their tooth extraction or oral surgery in case of operating bleeding.

Mechanism of action

Tranexamic acid is a synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure.

Pharmacokinetics

After a single oral administration of two 650 mg tablets of LYSTEDA, the peak plasma concentration (Cmax ) occurred at approximately 3 hours (Tmax ). The absolute bioavailability of LYSTEDA in women aged 18-49 is approximately 45%. Following multiple oral doses (two 650 mg tablets three times daily). administration of LYSTEDA for 5 days, the mean C max increased by approximately 19% and the mean area under the plasma concentration-time curve (AUC) remained unchanged, compared to a single oral dose administration (two 650 mg tablets). Plasma concentrations reached steady state at the 5th dose of LYSTEDA on Day 2.

Side effects

The table below contains some of the side-effects associated with tranexamic acid, although these occur only rarely.

Tranexamic acid side-effects	What can I do if I experience this?
Feeling or being sick	Stick to simple meals - avoid rich and spicy food. If you are not already doing so, try taking the tablets after meals
Diarrhoea	Drink plenty of water to replace the lost fluids
Eyesight problems (such as problems with your colour vision)	Let your doctor know about this as soon as possible as your treatment will need to be reviewed

Chemical Properties

white crystalline powder

Uses

Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

Uses

Used as lysine analogue to characterize binding sites in plasminogen

Uses

Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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career henan chemical co

6YR

China

Since: 2014-12-17
Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho

INQUIRY

杨俊青

sales@coreychem.com

Amstat

Product Details

Company Profile Introduction

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career henan chemical co