Liranaftate

Price	$1
Package	1KG

Product Details

Product Name: Liranaftate	CAS No.: 88678-31-3
Min. Order: 1G	Purity: 98%
Supply Ability: 100KG	Release date: 2019/07/06

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Liranaftate Basic information

The third generation of dithiocarbamate antifungal Toxicity Synthesis method Liranaftate cream Uses

Product Name:	Liranaftate
Synonyms:	carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(5,6,7,8-tetrahydro-2-na;phthalenyl)ester;LIRANAFATE;LIRANAFTATE;M-732;(6-METHOXY-2-PYRIDINYL)-METHYLCARBAMOTHIOIC ACID O-(5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL) ESTER;PIRITETRATE;ZEFNART
CAS:	88678-31-3
MF:	C18H20N2O2S
MW:	328.4286
EINECS:	-0
Product Categories:	All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Liranaftate;API
Mol File:	88678-31-3.mol

Liranaftate Chemical Properties

Melting point	98.5-99.5°C
storage temp.	-20°C Freezer
Merck	14,5515

Safety Information

RTECS

FD3890000

MSDS Information

Liranaftate Usage And Synthesis

The third generation of dithiocarbamate antifungal	Liranaftate is a new king of third-generation dithiocarbamate antifungals , it is a new kind of the third category of chemicals,it belongs to squalene cyclooxygenase inhibitors, by inhibiting the fungal cell membrane squalene epoxidation reaction , it hinders the synthesis of ergosterol which is a constituent of cell membranes ,it plays the role of anti-fungal,its anti-fungal activity is 8 times of tolnaftate, and its dermatophytes effect is better than clotrimazole. It has a strong anti-fungal effect on skin filamentous fungi (Trichophyton,Microsporon, Epidermophyton) , it also shows antifungal activity on other filamentous fungi, dark fungi, dimorphic fungi.It is useful in the treatment of tinea capitis, ringworm, athlete's foot, tinea pedis, onychomycosis, tinea, jock itch, tinea versicolor and vulvovaginal candidiasis.
Toxicity	Reproductive toxicity: in general reproductive toxicity tests, subcutaneous administration to SD rats , the largest non-toxic dose for the parent is 20mg/kg, the largest non-toxic dose for the reproductive process and their pups is 100mg/kg. Genetic Toxicity: Liranaftate mutagenicity tests are negative. In toxicity tests during teratogenic sensitively period , subcutaneous administration ,the largest non-toxic dose of maternal is 300mg/kg, the largest non-toxic dose to fetal rats is100mg/kg. In perinatal toxicity tests, administer subcutaneously, the largest non-toxic dose for the mother and newborn pups is 30mg/kg. The above information is edited by the chemicalbook of Tian Ye.
Synthesis method	5,6,7,8-tetrahydro-2-naphthol reacts with thiophosgene to give the thio-5,6,7,8-tetrahydro-2-naphthyl chloroformate ester and 2-methoxy-6-methylamine pyridine, then react in isopropanol · water at room temperature for 2 hours to obtain liranaftate ,the overall yield is 70%.
Liranaftate cream	Liranaftate cream is a relatively safe topical antifungal formulation . In mutagenicity studies we found that no matter in chromosome aberration tests, or in the bone marrow micronucleus tests, Liranaftate cream has no effect on inducing cell chromosome aberrations , and it has no effect on bone marrow cell proliferation. It is used for the treatment of ringworm, athlete's foot, ringworm, jock itch, tinea versicolor and vulvovaginal candidiasis. Domestic manufacturers include: Chen Xin Shandong Lukang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052287), Beijing Sihuan Pharmaceutical Technology Co., Ltd. Beijing Shengde Lai Bao Pharmaceutical Co., Ltd., Jiangsu zhongdan Pharmaceutical Co., Ltd.( Country medicine accurate words H20052733 ),Henan Tian Fang Pharmaceutical Co., Ltd. (Country medicine accurate words H20052552), and Nanjing Shenghe Pharmaceutical Co., Ltd. (Country medicine accurate words H20052554), Shideda Pharmaceutical (Beijing) Co., Ltd. (Country medicine accurate words H20052742), Kunshan Reddy pharmaceutical Co., Ltd. (Country medicine accurate words H20052345), Hugang Xinya pharmaceutical (Yangzhou) Co., Ltd. (Country medicine accurate words H20070143), Shandong Weigao pharmaceutical Co., Ltd. (Country medicine accurate words H20070073), Yangtze River pharmaceutical Group Co., Ltd. ( Country medicine accurate words H20080036), Heyuante Fukang pharmaceutical Co., Ltd. (Country medicine accurate words H20080162), Shandong Liangfu pharmaceutical Co., Ltd. (Country medicine accurate words H20080187)
Uses	Broad-spectrum antifungal
Chemical Properties	White Crystalline Solid
Uses	A squalene epoxidase inhibitor. Used as an antifungal

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

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career henan chemical co