5-amino-1-methylquinolin-1-ium iodide
| Price | $100 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 100000kg/month |
| Update Time: | 2022-10-28 |
Product Details
| Product Name: 5-amino-1-methylquinolin-1-ium iodide | CAS No.: 42464-96-0 |
| Min. Order: 1kg | Purity: 99 |
| Supply Ability: 100000kg/month | Release date: 2022/10/28 |
Contract details
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Email:Grace@hebeisyjl.com
| Name | NNMTi |
|---|
| Description | NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[1]. NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[2]. |
|---|---|
| Related Catalog | Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease |
| In Vitro | NNMTi (10-30 µM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 µM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei)[2]. |
| In Vivo | NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU+ myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively[1]. NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice[1]. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature |
| SMILES | C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-] |
| References | [1]. Harshini Neelakantan, et al. Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem Pharmacol. 2019 May;163:481-492. [2]. Harshini Neelakantan, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem |
Company Profile Introduction
Hebei Gongyuan New Material Technology Co., Ltd is a company dedicated to the research and development, production and sales of organic compounds, pharmaceutical intermediates and chemical raw materials. The company has a long-term partnership with Chemical Industry Research Institute and its universities. It is a research and development enterprise of new pharmaceutical and chemical materials oriented to the global pharmaceutical market demand. Continuously innovate the world's leading new chemical and pharmaceutical products. It integrates the research and development, industrialization and market operation of innovative drugs. The company has strong technical strength, advanced equipment, strict quality management system and high-quality after-sales service. Over the years, our products have been widely sold to many countries and regions, and we have established stable cooperative relationships with traders and end users all over the world. We look forward to cooperating with you
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