Glimepiride
| Price | $1 |
| Package | 1kg |
| Min. Order: | 1g |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: Glimepiride | CAS No.: 93479-97-1 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
| Product：: AD68 |
| Glimepiride Basic information |
| Description References |
| Product Name: | Glimepiride |
| Synonyms: | AMARYL;3-ETHYL-2,5-DIHYDRO-4-METHYL-N-[2-[4-[[[[(TRANS-4-METHYLCYCLOHEXYL)AMINO]CARBONYL]AMINO]SULFONYL]PHENYL]ETHYL]-2-OXO-1H-PYRROLE-1-CARBOXAMIDE;3-ETHYL-2,5-DIHYDRO-4-METHYL-N-[2-[4-[[[[(TRANS-4-METHYLCYCLOHEXYL)AMINO]CARBONYL]AMINO]SULFONYL]PHENYL]ETHYL]-2-OXO-1H-PYRROLE-1-CARBOXYAMIDE;Gliclazide(diamicron);CLIMEPIRIDE;Glimpiride;3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxyamide;1H-Pyrrole-1-carboxamide, 3-ethyl-2,5-dihydro-4-methyl-N-2-4-(trans-4-methylcyclohexyl)aminocarbonylaminosulfonylphenylethyl-2-oxo- |
| CAS: | 93479-97-1 |
| MF: | C24H34N4O5S |
| MW: | 490.62 |
| EINECS: | 999-999-2 |
| Product Categories: | Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Monovalent Ion Channels;Potassium Channel Modulators;Voltage-gated Ion Channels;API's;Chiral Reagents;Heterocycles;Sulfur & Selenium Compounds;API;NEURONTIN;Diabetes Research |
| Mol File: | 93479-97-1.mol |
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| Glimepiride Chemical Properties |
| Melting point | 212.2-214.5 °C |
| storage temp. | Room temp |
| solubility | DMSO: >10 mg/mL |
| form | solid |
| color | white |
| Merck | 14,4440 |
| CAS DataBase Reference | 93479-97-1(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 21-36/38-46-62-63 |
| Safety Statements | 25-26-36/37-53 |
| WGK Germany | 3 |
| RTECS | UX9363950 |
| MSDS Information |
| Provider | Language |
|---|---|
| Amary | English |
| SigmaAldrich | English |
| Glimepiride Usage And Synthesis |
| Description | Glimepiride (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation. Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin from functioning pancreatic beta cells and by increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin. Glimepiride is mainly used to treat patients with type 2 diabetes and can also decrease the chances that someone will develop complications of type 2 diabetes, such as kidney damage, blindness, nerve problems, loss of limbs, sexual function problems and heart attack or stroke. The drug was approved by the FDA in 1995 and is manufactured by Sanofi-Aventis. It can be used along with proper diet and exercise program and may also be used alone or with other antidiabetic medicines if need. The drug is available only with your doctor's prescription. |
| References | 1. https://en.wikipedia.org/wiki/Glimepiride 2. http://www.webmd.com/drugs/2/drug-12271/glimepiride-oral/details 3. https://www.drugs.com/cdi/glimepiride.html 4. http://www.medicinenet.com/glimepiride/article.htm 5. http://www.everydayhealth.com/drugs/glimepiride 6. http://www.emedicinehealth.com/drug-glimepiride/article_em.htm 7. https://www.ghc.org/kbase/topic.jhtml?docId=d03864a1 8. http://www.emedicinehealth.com/drug-glimepiride/article_em.htm 9. http://drugs.healthgrove.com/l/3454/Glimepiride |
| Chemical Properties | White Cyrstalline Solid |
| Uses | anticonvulsant |
| Uses | For concomitant use with insulin for the treatment of noninsulin-dependent (type 2) diabetes mellitus. |
| Uses | A sulfonylurea hypoglycemic agent. Used as an antidiabetic |
| Brand name | Amaryl (Sanofi Aventis). |
| Biological Activity | Potent K ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K ATP channels with an IC 50 of 6.8 nM. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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杨俊青
sales@coreychem.com
sales@coreychem.com