Product Details
| Product Name:
Cobicistat |
CAS No.:
1004316-88-4 |
| Min. Order:
1kg |
Purity:
99% |
| Supply Ability:
100kg |
Release date:
2019/07/06 |
| Product NUmber: :
WM.562 |
| Cobicistat Basic information |
| Description In vitro |
| Product Name: |
Cobicistat |
| Synonyms: |
Cobicistat;Cobicistat (GS-9350);thiazol-5-ylMethyl (2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)Methyl)-3-Methylureido)-4-MorpholinobutanaMido)-1,6-diphenylhexan-2-ylcarbaMate;GS 9350;GS9350;GS-9350;Cobicistat D8;(3R,6R,9S)-12-Methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester |
| CAS: |
1004316-88-4 |
| MF: |
C40H53N7O5S2 |
| MW: |
776.02272 |
| EINECS: |
|
| Product Categories: |
Inhibitor;Inhibitors |
| Mol File: |
1004316-88-4.mol |
 |
| |
| Cobicistat Chemical Properties |
| density |
1.228±0.06 g/cm3 (20 ºC 760 Torr) |
| |
| Cobicistat Usage And Synthesis |
| Description |
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
| In vitro |
Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir. |
| Uses |
Cobicistat is a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. |
| Uses |
Isotope labelled analogue of Cobicistat (C633150), a HIV protease inhibitor and have been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations. |
| Uses |
Antiretroviral;Labeled Cobicistat, intended for use as an internal standard for the quantification of Cobicistat by GC- or LC-mass spectrometry. |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$0.00/1KG |
VIP2Y
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Henan Aochuang Chemical Co.,Ltd.
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2022-10-13 |
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2021-07-10 |
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VIP4Y
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Baoji Guokang Bio-Technology Co., Ltd.
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2021-06-04 |
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$15.00/1KG |
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Zhuozhou Wenxi import and Export Co., Ltd
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2021-07-08 |
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$2063.00/1g/Bag |
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Zhuozhou Wenxi import and Export Co., Ltd
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2021-07-02 |
China