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Postion:Product Catalog >Biochemical Engineering>Inhibitors>protein tyrosine kinase>XL518
XL518
  • XL518
  • XL518

XL518

Price $2
Package 1kg
Min. Order: 1kg
Supply Ability: 100kg
Update Time: 2019-07-06

Product Details

Product Name: XL518 CAS No.: 934660-93-2
Min. Order: 1kg Purity: 99%
Supply Ability: 100kg Release date: 2019/07/06
Product Number:: WM.819
 
 
XL518 Basic information
Product Name: XL518
Synonyms: XL518;GDC-0973;RG7420;[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]Methanone;GDC-0973(XL-518);(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)Methanone;XL518 ,GDC-0973;CobiMetinib
CAS: 934660-93-2
MF: C21H21F3IN3O2
MW: 531.3100196
EINECS:  
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;API;MAPK
Mol File: 934660-93-2.mol
Article illustration
 
XL518 Chemical Properties
density  1.706
 
Safety Information
MSDS Information
 
 
XL518 Usage And Synthesis
Uses A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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