LIQUIRITIGENIN
| Price | $1 |
| Package | 1kg |
| Min. Order: | 1g |
| Supply Ability: | 100KG |
| Update Time: | 2019-07-06 |
Product Details
| Product Name: LIQUIRITIGENIN | CAS No.: 578-86-9 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 100KG | Release date: 2019/07/06 |
| Product : AD68 |
| LIQUIRITIGENIN Basic information |
| Description References |
| Product Name: | LIQUIRITIGENIN |
| Synonyms: | 4',7-DIHYDROXYFLAVANONE;7,4'-DIHYDROXYFLAVANONE;LIQUIRITIGENIN;LIQUIRITIGENIN(P);LIQUIRITIGENIN WITH HPLC;7,4''-DIHYDROXYFLAVANONE hplc;(2S)-2α-(4-Hydroxyphenyl)-7-hydroxy-2,3-dihydro-4H-1-benzopyran-4-one;(2S)-2α-(4-Hydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one |
| CAS: | 578-86-9 |
| MF: | C15H12O4 |
| MW: | 256.25 |
| EINECS: | |
| Product Categories: | Flavanones;sy;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 578-86-9.mol |
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| LIQUIRITIGENIN Chemical Properties |
| Melting point | 206-208°C |
| Fp | 207℃ |
| Safety Information |
| HS Code | 29329990 |
| MSDS Information |
| LIQUIRITIGENIN Usage And Synthesis |
| Description | Liquiritigenin is an active estrogenic component in extracts of Glycyrrhizae radix. Glycyrrhizae radix (G. radix, licorice, liquorice) is frequently used for life-enhancing properties, for the treatment of injury or swelling, for detoxification in traditional Oriental medicine, as well as a food supplement in many of the countries in the world. Liquiritigenin is a selective estrogen receptor-β (ERβ) agonist. Liquiritigenin activates multiple ER regulatory elements and native target genes with ERβ but not ERα. The ERβ-selectivity of liquiritigenin is due to the selective recruitment of the coactivator steroid receptor coactivator-2 to target genes. As the targeting ERβ is associated with anti-inflammatory effects, liquiritigenin exerts anti-inflammatory effects. Liquiritigenin is also reported to antihyperlipidemic, antiallergic and antihepatocellular carcinoma effects. |
| References | [1] J. E. Mersereau, N. Levy, R. E. Staub, S. Baggett, T. Zogric, S. Chow, W. A. Ricke, M. Tagliaferri, I. Cohen, L. F. Bjeldanes (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist, Molecular and Cellular Endocrinology, 283, 49-57 [2] Di Wang, Jiahui Lu, Yan Liu, Qingfan Meng, Jing Xie, Zhenzuo Wang,Lesheng Teng (2014) Liquiritigenin Induces Tumor Cell Death through Mitogen-Activated Protein Kinase- (MPAKs-) Mediated Pathway in Hepatocellular Carcinoma Cells, BioMed Research International, 2014, Article ID 965316 |
| Definition | ChEBI: A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta. |
| Purification Methods | It crystallises from aqueous 50% EtOH. [Beilstein 18 III/IV 1780, 18/4 V 82.] |
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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China- Since: 2014-12-17
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杨俊青
sales@coreychem.com
sales@coreychem.com