5,6-dihydro-5-Fluorouracil NEW
| Price | $223 | $423 | $980 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: 5,6-dihydro-5-Fluorouracil | CAS No.: 696-06-0 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | 5,6-dihydro-5-Fluorouracil |
| Description | 5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism. |
| In vitro | The combination of 5,6-dihydro-5-Fluorouracil (5-Fu) and NSC 123127 (Dox) demonstrates synergistic anticancer efficacy. The IC50 values for 5-Fu/Dox-DNM against human breast cancer (MDA-MB-231) cells are 0.25 μg/mL, with cytotoxicity increasing by 11.2-fold and 6.1-fold for Dox-DNM and 5-Fu-DNM, respectively [4]. In NFBD1-inhibited NPC cells treated with 5,6-dihydro-5-Fluorouracil (5-FU) and CDDP, lentivirus-mediated short hairpin RNA depletion of NFBD1 expression in NPC CNE1 cell line enhances sensitivity. Knockdown of NFBD1 significantly induces apoptosis in CNE1 cells treated with CDDP or 5,6-dihydro-5-Fluorouracil [2]. |
| In vivo | Administered at a dose of 23 mg/kg three times a week for 14 days, 5,6-dihydro-5-Fluorouracil(5-FU) induces gastrointestinal transit acceleration associated with acute intestinal inflammation starting on the third day of treatment. This may lead to sustained changes in the enteric nervous system (ENS) observed beyond the 7th day, and the 14-day treatment results in delayed gastrointestinal transit and colonic motility disorders [1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 43 mg/mL (325.53 mM), Sonication is recommended. PBS (pH 7.2) : 8 mg/mL Ethanol : 0.8 mg/mL DMF : 60 mg/mL |
| Keywords | 5,6dihydro5Fluorouracil | 5,6-dihydro-5-Fluorouracil | 5,6 dihydro 5 Fluorouracil |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hills
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