Norfloxacin Nicontinate

Product Name: Norfloxacin hydrochloride
Synonyms: 1-Ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1, 4-dihydroquinoline-3-carboxylic acid hydrochloride; Norfloxacin HCl
Assay: 98%
CAS No.: 104142-93-0
EINECS No.: 200-803-8
Molecular Formula: C16H19ClFN3O3
Molecular Weight: 355.7918
Boiling point: 573.8° C at 760 mmHg
Flashing point: 300.8° C
Appearance: White solid powder
Packing: As per your requirement
Application: Broad-spectrum antibiotic

Norfloxacin hydrochloride Pharmacological action:

This product is the main effect on the cell of DNA replication DNA gyrase subunit A process, blocking DNA replication, which inhibit the reproduction of bacteria to kill bacteria to.
1 direct interaction with pathogen nuclei, quickly and effectively kill the bacteria and Mycoplasma with DNA (or RNA) and protein synthesis ability of pathogens, and wide antimicrobial spectrum.
2 due to the destruction of the synthesis of nucleic acid, so that bacteria can not generate genetic information, so the cells to produce the mutation occurrence rate is low, no plasmid mediated resistance.
DNA gyrase DNA and bacterial pathogens of 3 different animal, the product is not sensitive, so the product of the high security.
This product absorbs quickly, quickly reach the peak plasma concentration, and the effective bactericidal concentration was maintained for a long time, against gram negative and gram positive bacteria is significant bactericidal effect at low concentration. Infection of good curative effect caused by Escherichia coli, Salmonella, Pseudomonas, bacillus, gram positive bacteria, the role of Staphylococcus aureus and other positive bacteria is very powerful. On the effects of Chicken Escherichia coli, Staphylococcus disease, pullorum disease, enteritis, fowl typhoid, avian paratyphoid. The enrofloxacin resistant strains are effective.

Usage and dosage

Livestock: Mixing the birds each 1000kg feed add norfloxacin (or salt) 100-200g, connect to use 3-5 days. Severe double.
The drinking bird per 1000kg of water added norfloxacin hydrochloride and norfloxacin nicotinate or norfloxacin lactate 50-100g, connect to use 3-5 days. Severe double.
Fisheries: Every 1000kg aquatic feed add norfloxacin (or salt) 150-300g, connect to use 5-7 days. Severe double.


Application:

Norfloxacin is used for prevention of spontaneous bacterial peritonitis in cirrhotic patients who have a low ascites fluid protein level, impaired renal function, severe liver disease, have had a prior episode of spontaneous bacterial peritonitis, or esophageal variceal bleeding.