Vinflunine

Product Name:

Vinflunine

Synonyms:

VINFLUNINE;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;Vinflunine Tartrate

CAS:

MF:

C45H54F2N4O8

MW:

816.93

EINECS:

1806241-263-5

Product Categories:

Miscellaneous Natural Products

Mol File:

162652-95-1.mol

 

Vinflunine Chemical Properties

CAS DataBase Reference

162652-95-1(CAS DataBase Reference)

 

Safety Information

MSDS Information

 

Vinflunine Usage And Synthesis

Description

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF₅) and in the presence of a chlorinated solvent like CHCl₃ or CCl₄.

Originator

Pierre Fabre (France)

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

Brand name

Javlor