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Postion:Product Catalog >API>Antibiotics>Macrolides>Dirithromycin
Dirithromycin
  • Dirithromycin

Dirithromycin

Price $3
Package 3KG
Min. Order: 1KG
Supply Ability: 100kg
Update Time: 2019-08-08

Product Details

Product Name: Dirithromycin CAS No.: 62013-04-1
Min. Order: 1KG Purity: 99%
Supply Ability: 100kg Release date: 2019/08/08
Product Model: windy

Dirithromycin

Modify Date: 2019-02-09 11:27:22
 
Article illustration
Dirithromycin structure
Article illustration Article illustration Article illustration
Common Name
Dirithromycin
CAS Number
62013-04-1
Molecular Weight
835.074
Density
1.2±0.1 g/cm3
Boiling Point
871.8±65.0 °C at 760 mmHg
Molecular Formula
C42H78N2O14
Melting Point
185 - 189ºC
MSDS
ChineseUSA
Flash Point
481.0±34.3 °C
Symbol
Article illustration 
GHS07
Signal Word
Warning

 Use of Dirithromycin

 
Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.Target: AntibacterialDirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues [1]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin. The spectrum of activity, adverse effect profile, clinical efficacy, and bacteriologic eradication rate of dirithromycin may be similar to those of erythromycin [2, 3].
  • Properties
  • Articles33
  • Spectrum

 Names

Name
dirithromycin
Synonym
More Synonyms

 Dirithromycin Biological Activity

Description
Dirithromycin(LY 237216) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.Target: AntibacterialDirithromycin is a new macrolide with a spectrum and degree of in vitro antimicrobial activity similar to that of erythromycin. Compared with erythromycin, dirithromycin has a long elimination half-life enabling once-daily administration, and it also achieves a greater cellular:extracellular concentration ratio and higher concentration in some tissues. Multicentre double-blind clinical trials have shown dirithromycin to be similar in efficacy to erythromycin in the treatment of uncomplicated bacterial infections of the respiratory tract and of skin and soft tissues [1]. Dirithromycin offers some attractive pharmacokinetic properties. The long elimination half-life of dirithromycin allows once-daily dosing and higher and more prolonged tissue concentrations than are achievable with erythromycin. The spectrum of activity, adverse effect profile, clinical efficacy, and bacteriologic eradication rate of dirithromycin may be similar to those of erythromycin [2, 3].
Related Catalog
Signaling Pathways >> Anti-infection >> Bacterial
Research Areas >> Infection
References

[1]. Brogden, R.N. and D.H. Peters, Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs, 1994. 48(4): p. 599-616.

[2]. Wintermeyer, S.M., S.M. Abdel-Rahman, and M.C. Nahata, Dirithromycin: a new macrolide. Ann Pharmacother, 1996. 30(10): p. 1141-9.

[3]. Sides, G.D., et al., Pharmacokinetics of dirithromycin. J Antimicrob Chemother, 1993. 31 Suppl C: p. 65-75.

 Chemical & Physical Properties

Density
1.2±0.1 g/cm3
Boiling Point
871.8±65.0 °C at 760 mmHg
Melting Point
185 - 189ºC
Molecular Formula
C42H78N2O14
Molecular Weight
835.074
Flash Point
481.0±34.3 °C
Exact Mass
834.545288
PSA
196.33000
LogP
2.84
Vapour Pressure
0.0±0.6 mmHg at 25°C
Index of Refraction
1.533

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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