PD 0325901

Product Name:

PD 0325901

Synonyms:

InSolution MEK1/2 Inhibitor III, PD0325901 - CAS 391210-10-9 - Calbiochem;MEK1/2 Inhibitor III - CAS 391210-10-9 - Calbiochem;PD0325901 (PD325901);PD-0235901;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be;PD325901;N-[(R)-2,3 -Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide;N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901

CAS:

MF:

C16H14F3IN2O4

MW:

482.191

EINECS:

687-152-7

Product Categories:

-;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor;Inhibitors;MAPK;API

Mol File:

391210-10-9.mol

 

PD 0325901 Chemical Properties

Melting point 

112-114°C

storage temp. 

Store at -20°C

solubility 

DMSO: soluble20mg/mL, clear

form 

White to off-white solid

color 

white to off-white

optical activity

[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol

InChIKey

SUDAHWBOROXANE-SECBINFHSA-N

 

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-48-50

Safety Statements 

22-36/37/39-61

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29242990

MSDS Information

 

PD 0325901 Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor

Definition

ChEBI: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).

Biological Activity

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with an IC50 of 0.33 nM, roughly 500-fold more potent than CI-1040 on the phosphorylation of ERK1 and ERK2.