Betaxolol hydrochloride

Product Name:

Daunorubicin

Synonyms:

(8s-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride;DAUNORUBICIN;DAUNORUBICINE HYDROCHLORIDE;DAUNOMYCIN;DAUNOMYCIN HYDROCHLORIDE;LEUKAEMOMYCIN C HYDROCHLORIDE;(8s-cis)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyrannosyl)oxy];3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naph

CAS:

MF:

C27H29NO10

MW:

527.52

EINECS:

244-069-7

Product Categories:

 

Mol File:

20830-81-3.mol

 

Daunorubicin Chemical Properties

Melting point 

155 °C

Boiling point 

608.13°C (rough estimate)

density 

1.3522 (rough estimate)

refractive index 

1.6400 (estimate)

pka

pKa 4.92±0.16(H2O t=25±0.5 I=0.03) (Uncertain)

CAS DataBase Reference

20830-81-3

EPA Substance Registry System

5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3, 6-trideoxy-.alpha.-L-lyxo- hexopyranosyl)oxy]-7,8,9, 10-tetrahydro-6,8,11-trihydroxy- 1-methoxy-, (8S,10S)-(20830-81-3)

 

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

20830-81-3(Hazardous Substances Data)

Toxicity

LD50 in mice, rats (mg/kg): 20, 13 i.v.; 5, 8 i.p. (DiMarco, 1977)

MSDS Information

 

Daunorubicin Usage And Synthesis

Chemical Properties

Daunomycin is a thin red, needle-shaped material.

Uses

antineoplastic

Uses

Oncology

Definition

ChEBI: A natural product found in Actinomadura roseola.

Indications

Daunorubicin (Cerubidine) is used to treat acute leukemias, while its structural analogue, doxorubicin (Adriamycin) is extensively employed against a broad spectrum of cancers. Although the two drugs have similar pharmacological and toxicological properties, doxorubicin is more potent against most animal and human tumors and will be discussed in greater detail.

Brand name

Cerubidine (Bedford); Cerubidine (Sanofi Aventis); Cerubidine (Wyeth).

General Description

Anthracycline antibiotic. An anticancer agent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human poison by ingestion. Experimental poison by subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also DAUNOMYCIN HYDROCHLORIDE.

Potential Exposure

An antibiotic. It is used as a medicine for treating cancer.

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required.

Waste Disposal

It is inappropriate and possi- bly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quanti- ties of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceuti- cal shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste con- taining this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.