1,4-PHENYLENE DIISOTHIOCYANATE

Product Name:

1,4-PHENYLENE DIISOTHIOCYANATE

Synonyms:

1,4-diisothiocyanato-benzen;1,4-diisothiocyanatobenzene[qr];1,4-phenylenedi-isothiocyanicaci;Phenylene-1,4-diisothiocyanate, 1,4-Diisothiocyanatobenzene;PDITC;p-Phenylene diisothiocyanate 98%;16842(uspddn)[qr];ai3-28258[qr]

CAS:

MF:

C8H4N2S2

MW:

192.26

EINECS:

223-741-3

Product Categories:

JONIT;reagent

Mol File:

4044-65-9.mol

 

1,4-PHENYLENE DIISOTHIOCYANATE Chemical Properties

Melting point 

129-131 °C(lit.)

density 

1.3675 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

−20°C

solubility 

chloroform: clear

form 

powder

color 

white

Water Solubility 

Hydrolyzes in water.

Sensitive 

Moisture Sensitive

Merck 

14,1308

BRN 

2414340

InChIKey

OMWQUXGVXQELIX-UHFFFAOYSA-N

CAS DataBase Reference

4044-65-9(CAS DataBase Reference)

 

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-42

Safety Statements 

22-26-36/37

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

RTECS 

NX9150000

F 

10-21

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29291090

Chemical Properties

off-white to yellow to beige-grey crystalline

Chemical Properties

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

Uses

Reagent for solid-phase sequencing.

Uses

anthelmintic

General Description

Odorless colorless crystals. Melting point 132°C.

Reactivity Profile

1,4-PHENYLENE DIISOTHIOCYANATE reacts readily with amines [Noller]. These reactions may generate significant amounts of heat . Emits very toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition [EPA, 1998].

Health Hazard

1,4-PHENYLENE DIISOTHIOCYANATE is highly toxic if ingested. It is a central nervous system and gastrointestinal toxin in humans.

Fire Hazard

When heated to decomposition, 1,4-PHENYLENE DIISOTHIOCYANATE emits very toxic fumes of nitrogen oxides and sulfur oxides.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: hallucinations, nausea. When heated to decomposition it emits very toxic fumes of NOx,CN,and SOx.See also THIOCYANATES

Potential Exposure

Those engaged in the manufacture, formulation and application of this anthelmintic compound. Incompatibilities: In general, keep away from strong oxidizers, moisture, strong acids, strong bases. This is a thiocyanate compound. Violent reactions may occur upon contact with chlorates (potassium chlorate, sodium chlorate), nitrates, nitric acid; organic peroxides.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required.

Purification Methods

Purify bitoscanate by recrystallisation from AcOH, pet ether (b 40-60o), Me2CO or aqueous Me2CO. [van der Kerk et al. Recl Trav Chim Pays-Bas 74 1262 1955, Leiber & Slutkin J Org Chem 27 2214 1962, Beilstein 13 IV 174.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.