![VX-770](https://img.chemicalbook.com/ProductImageEN/2019-9/Large/67949fe1-a79b-4704-b7f8-ef3ada6e3eb3.jpg)
VX-770
Price | $7 |
Package | 1KG |
Min. Order: | 1KG |
Supply Ability: | JD 485 |
Update Time: | 2019-09-02 |
Product Details
Product Name: VX-770 | CAS No.: 873054-44-5 |
Min. Order: 1KG | Purity: 99% |
Supply Ability: JD 485 | Release date: 2019/09/02 |
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Product Name:
VX-770
Synonyms:
873054-44-5;Ivacaftor;N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide;N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxaMide;Ivacaftor (VX-770);VX 770, Ivacaftor;Ivacaftor-D4;Kalydeco
CAS:
873054-44-5
MF:
C24H28N2O3
MW:
392.49072
EINECS:
-0
Product Categories:
-;API;Inhibitors
Mol File:
873054-44-5.mol
![Article illustration](https://www.chemicalbook.com/CAS/GIF/873054-44-5.gif)
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VX-770 Chemical Properties
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density
1.187
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Safety Information
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HS Code
29333990
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MSDS Information
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VX-770 Usage And Synthesis
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Description
In January 2012, the US FDA approved ivacaftor for the treatment of cystic fibrosis (CF) in patients who have the G551D mutation of the CF transmembrane regulator (CFTR) and are at least 6 years old. Ivacaftor (also known as VX-770) is a CFTR potentiator that increases the open probability of CFTR, thus increasing chloride secretion particularly in the 5% of CF patients with the G551D/F508 gating/ processing mutation. Ivacaftor was discovered by medicinal chemistry optimization of a lead scaffold identified through high-throughput screening of a 228,000 compound collection. In cultured bronchial epithelial cells from a CF patient with F508del, ivacaftor increased chloride secretion (EC50=81 nM). Preparation of ivacaftor is accomplished via a multistep synthesis oftwointermediates, 4-oxo-1,4-dihydroquinoline-3-carboxylic acid and 5-amino-di-tert-butylphenyl methyl carbonate, which are coupled using propane phosphonic acid anhydride (T3P) to afford the amide; deprotection of the phenol then provides ivacaftor.
Originator
Vertex Pharmaceuticals (United States)
Uses
Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively
Uses
Ivacaftor is used in the treatment of cystic fibrosis.
Definition
ChEBI: An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis.
Brand name
Kalydeco
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates:
Pharmaceutical intermediates;
OLED intermediates;
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- Since: 2014-12-17
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INQUIRY
杨俊青
sales@coreychem.com
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