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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Transmembrane Transporters>ATPase activator> OMecaMtiv Mecarbil
	OMecaMtiv Mecarbil
  • 	OMecaMtiv Mecarbil

OMecaMtiv Mecarbil

Price $1
Package 1ASSAYS
Min. Order: 1ASSAYS
Supply Ability: per week:100kg
Update Time: 2019-09-06

Product Details

Product Name: OMecaMtiv Mecarbil CAS No.: 873697-71-3
Min. Order: 1ASSAYS Purity: 95%~99%
Supply Ability: per week:100kg Release date: 2019/09/06
Mary014
OMecaMtiv Mecarbil Basic information
Description In vitro In vivo
Product Name:
OMecaMtiv Mecarbil
Synonyms:
CK 1827452 - Omecamtiv Mecarbil | CK-452;OMecaMtiv Mecarbil;OMecaMtiv Mecarbil (CK-1827452);CK1827452;CK-1827452;CK-1827452 (OMecaMtiv Mecarbil);CK 1827452O;mecamtiv mecarbil
CAS:
873697-71-3
MF:
C20H24FN5O3
MW:
401.4346632
EINECS:
 
Product Categories:
-;Inhibitors
Mol File:
873697-71-3.mol
Article illustration
 
OMecaMtiv Mecarbil Chemical Properties
Melting point 
180℃
 
Safety Information
MSDS Information
 
 
OMecaMtiv Mecarbil Usage And Synthesis
Description
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
In vitro
In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway. [
In vivo
Omecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
Uses
CK 1827452 is a promising new drug in systolic heart failure. It accelerates the transition of myosin into the force-generating state without affecting cardiac myocyte calcium homeostasis. CK 1827452 increases cardiac function by increasing the duration of ejection without changing the rates of contraction.
 
OMecaMtiv Mecarbil Preparation Products And Raw materials
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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